Back to search results

ERP for Veterans with OCD and PTSD

This study is looking at two types of therapy for Veterans with Obsessive Compulsive Disorder (OCD), including those who also have Post-Traumatic Stress Disorder (PTSD). You would receive either Exposure and Response Prevention (ERP), a specialized therapy for OCD, or Stress Management Training. Researchers want to see if these therapies improve how well you function in daily life, your quality of life, and your OCD symptoms. The study aims to enroll 160 Veterans receiving care at the Michael E. DeBakey VA Medical Center in Houston, TX. The current status of this study is unclear.

Study design
This study will compare two different therapies in 160 Veterans with OCD, half of whom also have PTSD. Participants will be randomly assigned to receive either ERP or Stress Management Training.
What's involved
You would attend 16 weekly therapy sessions. You would also complete assessments at the end of treatment and again 6 months later.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months after completing their treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05240924

ERP to Improve Functioning in Veterans With OCD

Recruiting
NAAges 18+InterventionalTreatment
VA Office of Research and Development
~160 participants
Updated 2026-06-08 on ClinicalTrials.gov
What's tested:Exposure and Response PreventionStress Management Training

At a glance

Recruiting sites
19 of 19 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Work and Social Adjustment Scale (WSAS) - Change
Measured over Baseline, Post Treatment (4-6 Months after Randomization), 6 Months Post Treatment

Conditions

Obsessive Compulsive Disorder (OCD)
Comorbid Post-Traumatic Stress Disorder and OCD

Explore related trials

Obsessive Compulsive DisorderPost-Traumatic Stress Disorder

Where it's being run

19 sites across 8 states
New York4
North Carolina4
Virginia3
Oregon2
Texas2
Washington2
New Jersey1
South Carolina1

Study leadership

  • Terri L. Fletcher, PhD · PRINCIPAL_INVESTIGATOR · Michael E. DeBakey VA Medical Center, Houston, TX

Who to contact

Terri L Fletcher, PhD
[email protected]
(713) 440-4400
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska: the VISN 2 Clinical Resource Hub which provides telehealth services to New Jersey, New York, and northern Pennsylvania, and the VISN 6 Clinical Resource Hub which provides telehealth services to North Carolina and Virginia.
Willingness to participate in Exposure and Response Prevention(ERP)

Exclusion

Significant cognitive impairment or conditions that threaten safety (current psychosis, mania, imminent suicidality including plan or intent, and treatment-interfering moderate to severe substance use).
Potential participants taking psychotropic medications must be on a stable dose of these medications for at least 6 weeks prior to study enrollment.

What this trial measures

  • Work and Social Adjustment Scale (WSAS) - ChangeBaseline, Post Treatment (4-6 Months after Randomization), 6 Months Post Treatment

    The WSAS is a 5-item, self-report measure of impairment and functioning across five domains: work, household tasks, relationships, social, and leisure functioning. Respondents rate the impairment due to a specified problem; study participants will be directed to respond regarding impairment caused by OCD. Each item is rated on a 0-8 scale; total scores range from 0 to 40. The WSAS has good internal consistency reliability and validity and has been used to assess changes in functioning in OCD and anxiety disorders in psychotherapy trials. A score of 0-9 (Low impairment), 10-19 (Moderate impairment), and 20-40 (Severe impairment).