Observational Study of FTT PET/CT in Metastatic Prostate Cancer

This observational study is looking at men with metastatic prostate cancer to see how a special imaging scan, called FTT PET/CT, can measure PARP activity in their cancer. PARP is a protein that helps repair damaged DNA in cancer cells. You would receive an investigational radiopharmaceutical called [18F]FluorThanatrace, which helps the FTT PET/CT scan show PARP activity. Up to 30 men will have at least one FTT PET/CT scan before starting a new treatment, and some may have a second scan after starting treatment. The study aims to see how well the FTT PET/CT scan measures PARP activity in the cancer. The current status of this study is unclear.

Study design
This is an observational study involving up to 30 men. It is not specified if it is blinded or what phase it is in.
What's involved
You would undergo up to two FTT PET/CT scans. The first scan is before starting new therapy, and the second, optional, scan is 1-21 days after starting treatment.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint measurement is taken at 21 days after starting treatment.

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NCT05242744

FTT PET/CT in Metastatic Prostate Cancer

Recruiting
Not specifiedAges 18+Observational
Abramson Cancer Center at Penn Medicine
~30 participants
Updated 2026-06-26 on ClinicalTrials.gov
What's tested:[18F]FluorThanatrace

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measurement of effect size
Measured over 21 days
Prostate Cancer Metastatic
1 sites across 1 states
Pennsylvania1
  • Neil Taunk, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

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  • Measurement of effect size21 days

    To establish effect size of change in FTT uptake before and after systemic therapy in men with prostate cancer metastasis using \[18F\]FluorThanatrace (\[18F\]FTT)