Computer Monitor vs. Augmented Reality 3MDR for PTSD

This study is comparing two ways to deliver a therapy called Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR) for post-traumatic stress disorder (PTSD). 3MDR is a "walk and talk" therapy where you walk on a treadmill and discuss trauma-related pictures with a therapist. This trial aims to enroll 60 military service members, veterans, retirees, or their dependents who have PTSD and can walk on a treadmill. The study will measure how well the therapy works by checking your PTSD symptoms using two common questionnaires (CAPS-5 and PCL5) three months after treatment. The current status of this study is unclear.

Study design
This is a randomized controlled trial comparing two different ways of delivering 3MDR therapy, involving 60 participants.
What's involved
You would attend 10-14 therapy sessions, each lasting 60-90 minutes, about once a week. Your symptoms will be assessed before, during, and after therapy.
Compensation
Not stated in the trial record.
Follow-up
Your symptoms will be assessed 3 and 6 months after completing therapy.

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NCT05244564

Computer Monitor vs Augmented Reality 3MDR for PTSD PTSD: A Randomized Controlled Trial

Recruiting
NAAges 18+InterventionalTreatment
Uniformed Services University of the Health Sciences
~60 participants
Updated 2025-07-15 on ClinicalTrials.gov
What's tested:Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinician Administered PTSD scale for DSM5 (CAPS-5)
Measured over 3 months
+1 more outcome measured
Stress Disorders, Post-Traumatic
1 sites across 1 states
Maryland1
  • Michael Roy, MD, MPH · PRINCIPAL_INVESTIGATOR · Unformed Services University

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Service member, veteran, retiree, or DEERS-eligible dependent, male or female, at least 18 years or older
Diagnosis of PTSD, as confirmed by the CAPS-5
Able to ambulate with contact guard assistance or less, and walk unassisted on a treadmill, at a normal pace, for up to 90 minutes continuously

Exclusion

History of epilepsy or a seizure disorder, other than febrile seizures that occurred during childhood and have not recurred since
History of a psychotic disorder, bipolar disorder, or active suicidal or homicidal ideation
Use of benzodiazepines on a regular basis within the previous 30 days
  • Clinician Administered PTSD scale for DSM5 (CAPS-5)3 months

    The primary outcome measure will be the Clinician Administered PTSD scale for DSM5 (CAPS-5), the gold standard measure for PTSD diagnosis, to assess PTSD symptom severity.

  • PTSD Checklist for DSM5 (PCL5)3 months

    The PTSD Checklist for DSM5 (PCL5), a well-validated 20-item self-report measure of PTSD symptom severity.