Living Donor Liver Transplant for Colorectal Liver Metastases

This study is looking at living donor liver transplantation (LDLT) for people with colorectal cancer that has spread to the liver (metastatic colorectal cancer) and cannot be removed by surgery. The study aims to collect information on patients who undergo this procedure to understand how well they do. Researchers will track how many patients are still alive and free from cancer recurrence after 5 years. You may be able to join if you are 18 or older, have colorectal cancer that has spread to the liver and cannot be cured by surgery, and are considered a candidate for LDLT by the University of Rochester liver transplant program. The current recruitment status is unclear.

Study design
This is an observational study that plans to enroll 25 participants. It is designed to collect data on patients undergoing living donor liver transplantation.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed to measure recurrence-free survival and overall survival at 5 years after the transplant.

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NCT05248581

Living Donor Liver Transplant for Unresectable Colorectal Liver Metastases

Recruiting
Not specifiedAges 18+Observational
University of Rochester
~25 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:Liver transplantation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
percentage of patients with recurrence free survival
Measured over 5 years
+1 more outcome measured
Colorectal Cancer Metastatic
1 sites across 1 states
New York1
  • Roberto Hernandez-Alejandro, MD · PRINCIPAL_INVESTIGATOR · University of Rochester
  • Matthew Byrne, MD · STUDY_DIRECTOR · University of Rochester

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Eligibility criteria

Inclusion

Age ≥ 18
Non-amenable to curative hepatic resection as defined by FLR \<30%
Histologically confirmed adenocarcinoma of the colon or rectum
Candidate for LDLT for colorectal liver metastasis per the University of Rochester liver transplant program

Exclusion

Not a candidate of the LDLT liver transplant protocol for treatment of colorectal liver metastasis.
Unwilling to consent
  • percentage of patients with recurrence free survival5 years

    RFS proportions to be calculated at 1, 3, and 5 years with Kaplan Meier analysis

  • percentage overall survival5 years

    OS proportions to be calculated at 1, 3, and 5 years with Kaplan Meier analysis