Testosterone Treatment for Men with Chronic Kidney Disease

This study is looking at how Jatenzo Pill, an oral testosterone medicine, affects men who have low testosterone (hypogonadism) and chronic kidney disease. Researchers want to see if Jatenzo Pill can increase testosterone levels, improve red blood cells (hemoglobin), muscle strength, and sexual function. You might be able to join if you are a man between 18 and 85 years old, have chronic kidney disease (eGFR 15-45 ml/min/1.73m2), and have low testosterone levels (below 300 ng/dl on two separate occasions) along with symptoms like low sex drive or fatigue. The main goal is to measure your testosterone levels after 6 months of treatment. The study is currently unclear on its recruitment status and plans to enroll 20 participants.

Study design
This is an interventional study with 20 planned participants. It will evaluate the effects of Jatenzo Pill.
What's involved
You would take Jatenzo Pill daily for 6 months. You would have research visits every 2-4 weeks, which include blood draws, physical exams, vital signs, questionnaires, body scans, and muscle strength tests.
Compensation
Not stated in the trial record.
Follow-up
Testosterone concentrations are measured at 6 months, which is the duration of the drug treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05249634

Testosterone Treatment in Men With Chronic Kidney Disease

Recruiting
PHASE2Ages 18–85InterventionalTreatment
St. Louis University
~20 participants
Updated 2026-04-30 on ClinicalTrials.gov
What's tested:Jatenzo Pill

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Testosterone concentrations
Measured over 6 months
Hypogonadism, Male
Kidney Disease, Chronic
1 sites across 1 states
Missouri1
  • Sandeep Dhindsa, MD · PRINCIPAL_INVESTIGATOR · St. Louis University

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Men between ages of 18-85 years of age
eGFR 15-45 ml/min/1.73m2 by MDRD (Modification of Diet in Renal Disease) equation
Subnormal total serum T concentrations (\<300 ng/dl) on two separate occasions in morning
Symptoms of hypogonadism (as per Endocrine Society guidelines): low libido, erectile dysfunction, fatigue, irritability, depressed mood, poor concentration, increased body fat, decreased muscle bulk, reduced physical performance, sleep disturbance, loss of body hair (15)
Normal iron stores as defined by serum ferritin ≥100 ng/mL and transferrin saturation (TSAT) ≥20%.

Exclusion

Use of TRT currently or in the past 6 months, including use of over-the-counter androgen containing health supplements (e.g., DHEA)
Hematocrit \>48% (as per Endocrine Society guidelines)(15)
Treatment with erythropoiesis stimulating agents (ESA)
Uncontrolled blood pressure (\>180/100 mm Hg)
Heart Failure, class III or IV
Myocardial infarction, stroke, or heart surgery in the past 3 months
Breast cancer
History of prostate cancer
Prostate specific antigen (PSA) \>4 ng/ml, unless prostate cancer has been ruled out by a urologist (documented in physician notes)
HIV or untreated hepatitis C
Untreated, severe obstructive sleep apnea
Initiated iron replacement in the last 3 months
deep venous thrombosis or pulmonary embolism in the last 3 months
recurrent (more than once) deep venous thrombosis or pulmonary embolism
use of warfarin
Planning to have children in the next one year
  • Testosterone concentrations6 months

    Testosterone concentrations in serum measured multiple times during the study