Ventripoint Single Ventricle Study
This study is looking at a new way to measure heart size and function in children and young adults who have a condition called functional single ventricle (a type of congenital heart disease where only one of the heart's two pumping chambers works effectively). It uses a special 3D ultrasound called Ventripoint Echocardiogram, which is a non-invasive way to look at your heart. Researchers want to see how accurate this new method is compared to standard imaging tests like a regular echocardiogram or a cardiac MRI. The main goal is to measure how well the heart's pumping chambers (right and left ventricles) are working and their size on the first day of the study. Anyone with a functional single ventricle, regardless of age or previous surgeries, who is already having a standard echocardiogram or cardiac MRI can join. The study is planning to enroll 100 participants, but its current status is unclear.
- Study design
- This is an interventional study that plans to enroll 100 participants. It will compare a new 3D ultrasound technique to standard imaging methods.
- What's involved
- You would undergo a Ventripoint Echocardiogram, which is a non-invasive ultrasound of the heart. This would be in addition to a clinically ordered transthoracic echocardiogram and/or cardiac MRI you are already having.
- Compensation
- Not stated in the trial record.
- Follow-up
- Cardiac function and ventricular dimension are measured on Day 1. No further follow-up is specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Ventripoint Single Ventricle Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Piers Barker, MD · PRINCIPAL_INVESTIGATOR · Duke University
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Cardiac function of the right ventricle as measured by ejection fractionDay 1
Ejection Fraction (EF) is a measurement of the percentage of blood leaving your heart each time it squeezes (contracts)with each heart beat.
- Cardiac function of the left ventricle as measured by ejection fractionDay 1
Ejection Fraction (EF) is a measurement of the percentage of blood leaving your heart each time it squeezes (contracts)with each heart beat.
- Right ventricular dimension as measured by end diastolic volumeDay 1
End Diastolic Volume (EDV) is the volume of blood in a ventricle at end load or filling in (diastole) or the amount of blood in the ventricles just before systole.
- Right ventricular dimension as measured by end systolic volumeDay 1
End Systolic Volume (ESV) is the volume of blood in a ventricle at the end of contraction, or systole, and the beginning of filling, or diastole.
- Left Ventricular Dimension as measured by end diastolic volumeDay 1
End Diastolic Volume (EDV) is the volume of blood in a ventricle at end load or filling in (diastole) or the amount of blood in the ventricles just before systole.
- Left Ventricular Dimension as measured by end systolic volumeDay 1
End Systolic Volume (ESV) is the volume of blood in a ventricle at the end of contraction, or systole, and the beginning of filling, or diastole.
- Left Ventricular Dimension as measured by end diastolic diameterDay 1
End Diastolic Diameter (EDD) is the diameter across the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter.
- Left Ventricular Dimension as measured by end systolic diameterDay 1
End Systolic Diameter (ESD) is the diameter across the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter.
- Right Ventricular Function as measured by tricuspid annular plane systolic excursionDay 1
Tricuspid Annular Plane Systolic Excursion (TAPSE) is a measurement of the decent of the right ventricular base towards a relatively fixed apex.
- Right Ventricular Function as measured by myocardial performance indexDay 1
RV Myocardial Performance Index (MPI) is a measurement that incorporates tricuspid valve closure to opening time and right ventricular ejection time to evaluate efficiency of the ventricle.
- Left Ventricular Function as measured by myocardial performance indexDay 1
LV Myocardial Performance Index (MPI) is a measurement that incorporates mitral valve closure to opening time and left ventricular ejection time to evaluate efficiency of the ventricle.
- Left Ventricular Function as measured by tissue doppler imagingDay 1
Tissue Doppler Imaging (TDI) a measurement of the velocity of myocardial motion.
- Left ventricular function as measured by shortening fractionDay 1
Shortening fraction(SF) is a measurement of the percentage of change in left ventricular diameter during systole.
- Presence of ventricular dysfunction as measured by strainDay 1
Strain is a measure of deformity in the muscle of the ventricle.