The YOUNG LUNG Study: Understanding Lung Cancer in Young Adults

This observational study, called The YOUNG LUNG Study, aims to better understand lung cancer (Non-Small Cell Lung Cancer or Small Cell Lung Carcinoma) in people aged 45 or younger. Researchers want to learn about the causes, risks, and genetic changes associated with lung cancer in this younger age group to improve screening and treatment. You could participate if you were diagnosed with lung cancer at age 45 or younger and are willing to provide medical records, answer two short questionnaires, and give blood and/or saliva samples. The study plans to enroll about 500 people and will collect specimens and data for up to 5 years or until the study closes.

Study design
This is an observational study that aims to enroll about 500 participants. It is not testing a specific drug or treatment.
What's involved
You would provide access to your medical records, answer two short questionnaires, and give up to 5 tubes of blood and/or a saliva sample. You may also consider providing tumor tissue samples.
Compensation
Not stated in the trial record.
Follow-up
Participants will be in this study until it closes or they withdraw consent. The primary endpoint involves collecting specimens and data for up to 5 years or until study closure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05265429

Biology of Young Lung Cancer Study: The YOUNG LUNG Study

Recruiting
Not specifiedAges 15+Observational
Dana-Farber Cancer Institute
~500 participants
Updated 2025-10-29 on ClinicalTrials.gov
What's tested:Data and Specimen Collection

At a glance

Recruiting sites
2 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Repository of specimens and data
Measured over 5 years or study closure
Non Small Cell Lung Cancer
Small Cell Lung Carcinoma
NUT Carcinoma
4 sites across 1 states
Massachusetts4
  • Pasi A Janne, MD, PhD · PRINCIPAL_INVESTIGATOR · Dana-Farber Cancer Institute

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Eligibility criteria

Inclusion

Age 45 and under at lung cancer diagnosis
Pathologically confirmed bronchogenic lung carcinoma (NSCLC or SCLC of any stage) at any treatment time point
Provision of written informed consent
Willingness to undergo no more than two (2) peripheral blood draws in a four (4) week period, with no more than 50 ml peripheral blood collected over eight (8) weeks
Individuals under age 18 are eligible for study if they meet defined criteria; in addition, consent for participation must be given by a legal guardian or parent

Exclusion

Individuals who decline to sign consent
Individuals who are unable to give consent or assent and are without a designated healthcare proxy
Compromise of patient diagnosis or staging if tissue is used for research
  • Repository of specimens and data5 years or study closure

    Prospective registry of young lung cancer specimens for exploratory tumor and germline genomics, transcriptomics/proteomics, and future biomarker study.