Neuroimaging Study for Developmental Language Disorder
This study is looking at how the brain changes in children with Developmental Language Disorder (DLD), also known as specific language impairment, when they receive treatment. Researchers will use brain imaging (neuroimaging) and behavioral tests to understand how grammar learning works and how it's affected by DLD. They are testing a computer-assisted program called "My Sentence Builder" to see if it helps improve expressive grammar. The study aims to enroll 100 children between 48 and 71 months old who have DLD affecting their expressive grammar, or who are typically developing. The main goal is to see how brain connections change with treatment and over time.
- Study design
- This is an interventional study planning to enroll 100 participants. The study will look at changes in brain functional connectivity.
- What's involved
- Functional connectivity data will be measured at the beginning of the study, after treatment (up to 14 weeks), and at a follow-up point (27 to 28 weeks).
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for up to 28 weeks after the start of the study.
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Neuroimaging Reveals Treatment-related Changes in DLD
At a glance
Conditions
NCT05268341
Where you'd take part
This study runs at 6 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Cincinnati Children's Hospital
Cincinnati, Ohiostudy coordinator listed
Not yet recruiting
CWFF CHild Development Center
Cincinnati, Ohiostudy coordinator listed
Recruiting
Empower Learn Create INC
Cincinnati, Ohiostudy coordinator listed
Recruiting
New Horizon Childcare
Cincinati, Ohiostudy coordinator listed
Not yet recruiting
University of Cincinnati
Cincinnati, Ohiostudy coordinator listed
Recruiting
Wesley Education Center for Children and Families
Cincinnati, Ohiostudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Karla N Washington, PhD · PRINCIPAL_INVESTIGATOR · University of Cincinnati
Who to contact
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Inclusion
Exclusion
What this trial measures
- Functional connectivity data (time 1) from typical and DLD preschoolersTime 1 (pre)
Aim 1 (all TD and DLD preschoolers)- Primary: Pre/Time 1 data for functional connectivity (assessed using fMRI from the Sentence Completion Expressive Language Task- Preschool (SCELT-P)) between Regions of Interest (ROI) in the procedural learning network and in the declarative memory network
- Functional connectivity data DLD preschoolers only to assess changes with treatmentPre-to-post (up to 14 weeks), post-to-followup (at 27 to 28 weeks)
Primary: Pre-to-post changes and maintenance of changes post-to-followup in functional connectivity (assessed using fMRI from the SCELT-P) between ROI within the procedural learning network and within the declarative memory network.
- Functional connectivity data for typically developing and DLD preschoolers to assess changes in developmentpre-to-follow-up (up to 28 weeks)
Changes in development (pre-to-followup) in functional connectivity (assessed using fMRI from the SCELT-P) between ROI within the procedural learning and declarative memory networks.