Miraculin for Taste Dysfunction in Head and Neck Cancer Patients
This study is looking at whether a dietary supplement called Miraculin can help head and neck cancer patients who experience taste changes during radiation therapy. Many patients receiving radiation for head and neck cancer develop problems with their sense of taste, which can make it hard to eat. This study will give some patients Miraculin (a 'miracle fruit' cube) and others a placebo (an inactive cube that looks the same) three times a day before meals. Researchers will compare how these groups' taste changes over time, hoping to see if Miraculin can reduce the impact of taste changes on what patients eat. The study plans to enroll 40 participants aged 18 and older who have been diagnosed with head and neck cancer. The current status of the study is unclear.
- Study design
- This is a Phase III, double-blinded (meaning neither you nor your doctor will know if you're getting Miraculin or the placebo), placebo-controlled study that will randomly assign 40 participants to one of two groups.
- What's involved
- You would take a Miraculin or placebo cube three times a day before meals for up to 60 days, starting before your radiation treatment. Your taste will be assessed over time, up to 6 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 180 days after their treatment ends.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Addressing Taste Dysfunction With Miraculin in Head and Neck Cancer Patients Receiving Radiation Therapy
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Sue Yom, MD, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
What this trial measures
- Change in Taste Assessment scores over timeUp to 6 months
The Taste Assessment is a two-item questionnaire used to determine the overall experiences of the participant taste sensation in the past 7 days; with one item asking about taste alteration and another asking about the interference of taste alteration with dietary intake. Scores for each item are obtained by responses to a Likert scale ranging from 1= "not at all" to 5="a lot", with greater scores indicating a greater taste alteration or interference.