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NCT05273970

Electrochemical and Electrophysiological Study

Enrolling by Invitation
NAAges 18–80InterventionalBasic science
University of Arizona
~10 participants
Updated 2025-12-17 on ClinicalTrials.gov
What's tested:Behavioral testing under intracranial monitoring

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Neurotransmitter Concentration Fluctuation in Visual Memory
Measured over During Hospitalization - 1-2 weeks
+2 more outcomes measured

Conditions

Cognition
Medically Intractable Epilepsy

Explore related trials

Nervous System DisorderPsychiatric DisorderSeizure Disorder

Where it's being run

1 sites across 1 states
Arizona1

Study leadership

  • Robert Bina, MD · PRINCIPAL_INVESTIGATOR · University of Arizona

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18 to 80 years, inclusive.
Patients who are candidates for electrode implantation due to pharmacologically intractable epilepsy, or other neurological/psychological disorders for which subdural electrode implantation may be clinically required for treatment.
Patients competent to give informed consent/assent for the research protocol and parents of children under 18 who are competent to give informed consent on behalf of the child.
Fluency in English (necessary for uniform cognitive testing).
Committee approved candidates for brain surgery.
Medications must be at stable doses for at least 1 month before surgery

Exclusion

Clinically significant cognitive dysfunction.
Terminal illness associated with \<12 month survival.
Contraindication to MRI imaging, e.g., morbid obesity, metallic devices such as cardiac pacemakers, some aneurysm clips, or shrapnel.
Current pregnancy or pregnancy planned during the course of the study.
Cognitive function less than 2 standard deviations below normal on preoperative neuropsychological testing

What this trial measures

  • Neurotransmitter Concentration Fluctuation in Visual MemoryDuring Hospitalization - 1-2 weeks

    Neurotransmitter concentrations will be recorded through Fast Scan Cyclic Voltammetric methods during cognitive psychological tasks for visual memory administered on a laptop.

  • Neurotransmitter Concentration Fluctuation and Pupillary Diameter in Sustained Attention TasksDuring Hospitalization - 1-2 weeks

    Neurotransmitter concentrations will be recorded through Fast Scan Cyclic Voltammetric methods and and pupillary diameter will be observe with a pupillometer during cognitive psychological tasks for sustained attention administered on a laptop.

  • Neurotransmitter Concentration Fluctuation in Neuroeconomics TasksDuring Hospitalization - 1-2 weeks

    Neurotransmitter concentrations will be recorded through Fast Scan Cyclic Voltammetric methods during cognitive psychological tasks for neuroeconomics administered on a laptop.