Back to search results

Understanding Burn Wound Microbiome

This observational study aims to better understand the tiny living organisms (microbiome) in burn wounds. Researchers are comparing traditional ways of identifying these organisms with a newer, more advanced method called Next-Generation Sequencing. The goal is to see how these organisms might affect how burn wounds heal and any complications that arise. You may be able to join if you are an adult (18-100 years old) with a partial or full thickness burn wound that needs surgery. The study is looking for 400 participants, but its current status is unclear.

Study design
This is an observational study involving 400 adult participants. It compares two methods for identifying microorganisms in burn wounds.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will look at the correlation between the two methods over 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05275335

Understanding the Burn Wound Microbiome: Comparing Traditional Wound Cultures to Next Generation Sequencing Technology

Recruiting
Not specifiedAges 18+Observational
The University of Texas Medical Branch, Galveston
~400 participants
Updated 2025-08-15 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Statistical correlation of the Next-Generation Sequenced microbiome to standard culture results in burn wounds
Measured over 3 years

Conditions

Microbial Colonization
Burns

Explore related trials

Burn

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Steven E Wolf, MD · PRINCIPAL_INVESTIGATOR · University of Texas

Who to contact

Steven E Wolf, MD
[email protected]
12107870507
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

All adult patients (18 years of age and greater) admitted to or consulted by the Acute Burn Surgery service with a diagnosis of a partial thickness or full thickness burn wound determined by the Acute Burn Surgery service to be appropriate for operative intervention. We will include patients 18 years of age and older of any gender, race, prior therapy, or pre-existing medical condition. We will also include subjects in special classes, including pregnant women and cognitively impaired persons.

Exclusion

Children (less than 18 years of age) will be excluded. Patients who do not undergo operative therapy or patients whose operative therapy does not involve tangential excision of burn wounds will also not be eligible for inclusion by virtue of not being able to provide appropriate biospecimens. Patients whose burn wounds are isolated to the genitalia and perineum will be excluded from the study. For patients who have multiple burn wounds including those to the genitalia and perineum, it should be noted that excised tissues from the genitalia and perineum are not eligible for inclusion to the Burn Wound Data/Bio-Repository. Finally, patients whose operative intervention results in less than a total of 4 grams of discarded tissue will be excluded due to insufficient specimen for proper tissue analysis. Any tissue allocated for pathology or that has already been physically discarded into a trash receptacle will not be eligible for inclusion in the Burn Wound Data/Bio-Repository. We will also exclude prisoners from this study.

What this trial measures

  • Statistical correlation of the Next-Generation Sequenced microbiome to standard culture results in burn wounds3 years

    The relationship between next-generation sequencing of the burn wound microbiome and traditional clinical culture techniques will be examined. In particular, comparisons will compare the bacterial microbiota of each sample with bacteria identified using standard clinical culture methods from the same sample. Correlations in taxonomic diversity will be done with linear regression and Pearson correlation.