DETECT II Study for Fuchs Endothelial Dystrophy

This study, called DETECT II, is testing two ways to treat Fuchs endothelial dystrophy (a condition where cells in the eye's cornea don't work well). It compares a standard surgery (DMEK) with a different surgery (Descemet Stripping Only, or DSO) combined with an eye drop called Ripasudil. Researchers want to see if these treatments improve your vision, measured by how well you can see with glasses or contacts after 12 months. You might be able to join if you are over 18, have Fuchs dystrophy, and meet specific criteria for your eye health. This study is currently unclear on its status and plans to enroll 60 patients.

Study design
This is a multi-center, placebo-controlled study that will randomly assign 60 patients with Fuchs endothelial dystrophy to different treatments. It is designed so that the people measuring the results won't know which treatment you received.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your vision will be measured at 12 months after treatment to see how well the treatments worked.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05275972

Descemet Endothelial Thickness Comparison Trial II

Recruiting
PHASE3Ages 18+InterventionalTreatment
Stanford University
~60 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:RipasudilPlacebo

At a glance

Recruiting sites
8 of 8 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Best spectacle-corrected visual acuity (BSCVA)
Measured over 12 months
Fuchs
Fuchs Dystrophy
Fuchs' Endothelial Dystrophy
8 sites across 5 states
California2
Oregon2
Pennsylvania2
Florida1
New Hampshire1
  • Jennifer Rose-Nussbaumer, MD · PRINCIPAL_INVESTIGATOR · Stanford University

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Dysfunctional endothelium from FECD with few guttata extending beyond 4.5 mm
Peripheral endothelial cell count \>1000 cells/mm2 in at least one quadrant
Good surgical candidate for either procedure as determined by the surgeon
Willingness to participate
Age greater than 18 years

Exclusion

Aphakia, anterior chamber IOL or scleral fixated IOL in study eye prior to or anticipated during EK
Pre-operative central sub-epithelial or stromal scarring that the investigator believes is visually significant and could impact post-operative stromal clarity assessment
Other primary endothelial dysfunction such as PPMD
Visually significant optic nerve or macular pathology
Hypotony (Intraocular pressure \<10mmHg)
Any prior intraocular surgery other than cataract surgery
\>3 clock hours of ANY anterior or posterior synechiae
\>1 quadrant of stromal corneal vascularization
Inability to comply with post-operative instructions (i.e. unable to position)
Pregnancy
  • Best spectacle-corrected visual acuity (BSCVA)12 months

    Best spectacle-corrected visual acuity (BSCVA)