Understanding Pain in Fibromyalgia and Rheumatoid Arthritis

This observational study aims to understand how pain is processed in people with Fibromyalgia (FM) and Rheumatoid Arthritis (RA). Researchers are looking at how these conditions might share similar ways of experiencing pain, even though FM is considered a 'nociplastic' pain syndrome (pain from changes in the nervous system) and RA is 'nociceptive' (pain from tissue damage). You can join if you are between 18 and 70 years old and have been diagnosed with FM or RA, or if you are a healthy volunteer without significant pain, fatigue, depression, or anxiety. The study will measure your pressure pain thresholds (how much pressure causes pain) at one hour to see how pain is experienced.

Study design
This is an observational study planning to enroll 150 participants, including those with Fibromyalgia, Rheumatoid Arthritis, and healthy volunteers.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pressure pain thresholds will be measured at one hour.

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NCT05277025

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Recruiting
Not specifiedAges 18–70Observational
University of Florida
~150 participants
Updated 2026-08-19 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pressure Pain Thresholds
Measured over One hour
Fibromyalgia
Rheumatoid Arthritis
1 sites across 1 states
Florida1
  • Roland Staud, M.D. · PRINCIPAL_INVESTIGATOR · University of Florida

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Eligibility criteria

Inclusion

Ages 18-70
Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
Fulfills the 2010 ACR-EULAR classification criteria for RA
Healthy volunteers: No significant pain/fatigue/depression/anxiety.

Exclusion

Diabetes
Cancer
Advanced liver, kidney or cardiovascular disease
Neuropathic pain
  • Pressure Pain ThresholdsOne hour

    Using an algometer pressure pain thresholds will be obtained several times at the upper and lower extremities