Brain Health in Youth at Risk for Type 2 Diabetes
This observational study is looking at brain health in young people (ages 12-17) who are at risk for Type 2 Diabetes (T2D). Researchers are observing how brain structure and function change over 21 months in three groups: those with normal weight, those with overweight/obesity, and those with overweight/obesity and dysglycemia (higher than normal blood sugar). The goal is to understand how factors like obesity and blood sugar levels might affect the brain as it develops. You might be able to join if you are 12-17 years old, can lie flat in an MRI scanner, and are fluent in English. The study is currently unclear on its recruitment status.
- Study design
- This is an observational study with a planned enrollment of 117 participants. It is not a drug trial, but rather observes changes over time.
- What's involved
- You would have two study visits, 21 months apart, which include an MRI scan and cognitive (thinking and memory) tests.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 21 months, with measurements taken at the beginning and end of this period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
At a glance
Conditions
Where it's being run
2 sites across 2 statesStudy leadership
- Tamara A Hershey, PhD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
- Silva Arslanian, MD · PRINCIPAL_INVESTIGATOR · UPMC Children's Hospital of Pittsburgh
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- hippocampal volume21 months - Visit 1 and Visit 2 are 21 months apart
To determine hippocampal volumes, investigators will use the validated, objective and semi-automatic segmentation program Automated MRI Brain Volumetry System (volBrain). Hippocampal volumes will be obtained for each subject at each visit for primary analyses. Left and right volumes will be averaged, since lateralized findings are not hypothesized.
- restricted fraction21 months - Visit 1 and Visit 2 are 21 months apart
Investigators will use Diffusion Basis Spectrum Imaging (DBSI) models on diffusion weighted images (DWI) to assess restricted fraction within the hippocampus and throughout white matter tracts.
- Whole brain cerebral blood flow21 months - Visit 1 and Visit 2 are 21 months apart
Pseudo-continuous arterial spin labeling (pCASL) will be used to measure cerebral blood flow (CBF) implemented with an arterial spin labeling (ASL) sequence 228 and volume navigators (vNavs) to minimize motion artifact. Global CBF across pairs of frames will be scaled additively to the median value. Investigators will assess the number of voxels that statistically deviate from a normative value ('distributed deviating voxels') and compared between groups.
- Declarative Memory21 months - Visit 1 and Visit 2 are 21 months apart
Investigators will use the total score from the Paired Associates Memory Test, an experimental cognitive task measuring delayed declarative memory
- Processing speed21 months - Visit 1 and Visit 2 are 21 months apart
Investigators will use the raw scores from the NIH Toolbox Pattern Comparison Processing Speed task.
- Executive Function21 months - Visit 1 and Visit 2 are 21 months apart
Investigators will use an average of the (z scores) from the NIH Toolbox Flanker Inhibitory Control \& Attention, Dimensional Change Card Sort and List Sorting tasks.