Dupixent and Narrowband UVB for Atopic Dermatitis

This study is looking at how well Dupixent (dupilumab 300mg) works when combined with narrowband UVB phototherapy for people with moderate to severe atopic dermatitis (a type of eczema). You may be able to join if you are an adult aged 18 or older with moderate to severe atopic dermatitis, meaning you have an EASI score of 16 or higher, an IGA score of 3 or higher, and at least 10% of your body affected. You cannot have used Dupixent before or be allergic to it. The researchers will know the treatment is successful if your skin clears up significantly, measured by an Investigators Global Assessment Score of 0 or 1, after 12 weeks. The current recruitment status is unclear.

Study design
This is an open-label study, meaning both you and the study team will know what treatment you are receiving. It plans to enroll 40 participants.
What's involved
You would receive Dupixent and narrowband UVB phototherapy three times a week for 12 weeks, followed by 12 weeks of Dupixent alone.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at 12 weeks, but the study lasts for 24 weeks.

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NCT05285839

Dupixent and Narrowband UVB for Atopic Dermatitis

Recruiting
PHASE4Ages 18+InterventionalTreatment
Psoriasis Treatment Center of Central New Jersey
~40 participants
Updated 2024-03-15 on ClinicalTrials.gov
What's tested:Dupixent

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Investigators Global Assessment Score of score of 0 or 1
Measured over 12 weeks
Atopic Dermatitis
1 sites across 1 states
New Jersey1

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Eligibility criteria

Inclusion

Male or female adult ≥ 18 years of age;
Diagnosis of moderate to severe atopic dermatitis as defined at baseline by:
EASI score of 16 or greater,
IGA score of 3 or greater
BSA of 10% or greater,

Exclusion

Subjects with previous exposure to dupilumab.
Known or suspected hypersensitivity to dupilumab or any of its excipients.
History of photosensitivity.
  • Investigators Global Assessment Score of score of 0 or 112 weeks

    Proportion of subjects achieving an IGA score of 0 or 1 with at least a 2 grade improvement at week 12