Probiotic for Gut Health and Heart Disease Risk in People with HIV Who Drink Alcohol

This study is looking at whether a dietary supplement (probiotic) can help people living with HIV who drink alcohol. Heavy drinking can change the bacteria in your gut, which may increase your risk of heart disease. Researchers want to see if taking a probiotic can improve these gut bacteria, reduce inflammation, and lower the risk of heart disease. You may be able to join if you are 18 to 89 years old, have HIV, and speak English. The study will measure changes in your gut bacteria (specifically, the Firmicutes to Bacteroidetes ratio) after 6 months to see if the probiotic is working. The current status of this study is unclear, and it plans to enroll 250 people.

Study design
This is an interventional study that plans to enroll 250 participants. It will compare a probiotic dietary supplement to a placebo sachet.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 6 months, indicating follow-up for at least this duration.

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NCT05288790

Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT

Recruiting
PHASE2Ages 18–89InterventionalTreatment
Vanderbilt University Medical Center
~250 participants
Updated 2026-08-27 on ClinicalTrials.gov
What's tested:ProbioticPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Firmicutes to Bacteroidetes ratio
Measured over 6 months
Microtia
Dysbiosis
Alcohol Drinking
HIV Infections
Cardiovascular Diseases
1 sites across 1 states
Tennessee1

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Eligibility criteria

Inclusion

HIV infected

Exclusion

Not fluent in English
  • Firmicutes to Bacteroidetes ratio6 months

    Dysbiosis