Intracranial Stimulation Mapping In Epilepsy

This study is looking at how direct electrical stimulation in the brain affects thinking abilities in people with epilepsy. It uses a method called functional mapping, which involves recording brain activity (intracranial EEG), observing behaviors, and applying electrical stimulation directly to the brain. The goal is to create maps of the brain that show where different functions are located and how different brain areas communicate in adults with partial epilepsy. You may be able to join if you are 18 or older, are currently having intracranial EEG monitoring for epilepsy surgery planning, and are willing to follow all study procedures. The study will measure the effect of brain stimulation on cognitive effort right after the stimulation sessions. The current recruitment status is unclear, and the study plans to enroll 30 participants.

Study design
This is a single-group study with 30 participants, looking at how brain stimulation affects cognitive effort. It is an interventional study, meaning participants will receive a specific intervention.
What's involved
You would undergo intracranial EEG data acquisition, observation and behavioral testing, and intracranial electrical stimulation. The study measures effects immediately after stimulation sessions.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured immediately after stimulation sessions, so long-term follow-up is not specified.

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NCT05290610

Intracranial Stimulation Mapping In Epilepsy

Recruiting
NAAges 18+InterventionalBasic science
University of Minnesota
~30 participants
Updated 2026-04-09 on ClinicalTrials.gov
What's tested:Functional mapping

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The effect of prefrontal direct electrical brain stimulation on cognitive effort
Measured over Immediately after stimulation sessions
Epilepsy
1 sites across 1 states
Minnesota1
  • Alexander Herman, MD · PRINCIPAL_INVESTIGATOR · UMN

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Eligibility criteria

Inclusion

Male or female 18 years and older at screening.
Written informed consent is obtained from the participant to comply with the requirements of the study.
Stated willingness to comply with all study procedures and availability for the duration of the study
Currently undergoing clinically indicated intracranial EEG monitoring for planning of epilepsy surgery in the University of Minnesota/MINCEP program.

Exclusion

Pregnancy ruled out prior to approval for intracranial EG monitoring.
Persons who are rendered temporarily or permanently invulnerable by inability to understand the research due to study complexity, cognitive impairment, or by inability to make independent decisions owing to University of Minnesota or to Fairview health services.
  • The effect of prefrontal direct electrical brain stimulation on cognitive effortImmediately after stimulation sessions

    The change in subjective value of cognitive effort (area under the curve) after direct electrical brain stimulation to different areas of the prefrontal cortex during an effortful task