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NCT05295446

Functional GI Disease Registry

Enrolling by Invitation
Not specifiedAges 18+Observational
Massachusetts General Hospital
~500 participants
Updated 2025-11-04 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Single Nucleotide Polymorphism (SNP) genotyping
Measured over Baseline visit
+10 more outcomes measured

Conditions

Functional Gastrointestinal Disorders

Explore related trials

Functional constipationFunctional diarrheaFunctional disorder of gastrointestinal tractIrritable Bowel SyndromeNauseaNonulcer dyspepsia

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Kyle Staller, MD MPH · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

18 years of age or older
Rome IV criteria for a functional GI disorder

Exclusion

Acute illness
Known bleeding disorder
Awaiting transplantation
Known diagnosis of Inflammatory Bowel Disease
Use of antibiotics in last 2 months

What this trial measures

  • Single Nucleotide Polymorphism (SNP) genotypingBaseline visit

    In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles.

  • Whole genome analysisBaseline visit

    In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles.

  • ProteomicsBaseline visit

    In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles.

  • Microbiome analysisBaseline visit

    In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles.

  • Microbiome analysis3 months after enrollment

    In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles.

  • Microbiome analysis6 months after enrollment

    In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles.

  • Microbiome analysis1 year after enrollment

    In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles.

  • Diet and Lifestyle QuestionnaireBaseline visit

    This questionnaire evaluates patients' diet, lifestyle, and symptoms relating to their functional GI disorder.

  • Diet and Lifestyle Questionnaire3 months after enrollment

    This questionnaire evaluates patients' diet, lifestyle, and symptoms relating to their functional GI disorder.

  • Diet and Lifestyle Questionnaire6 months after enrollment

    This questionnaire evaluates patients' diet, lifestyle, and symptoms relating to their functional GI disorder.

  • Diet and Lifestyle Questionnaire1 year after enrollment

    This questionnaire evaluates patients' diet, lifestyle, and symptoms relating to their functional GI disorder.