Real-time fMRI Neurofeedback for Schizophrenia with Auditory Hallucinations

This study is testing a treatment called stg-rt-fMRI-Neurofeedback, which uses real-time feedback from your brain activity to help reduce auditory hallucinations (hearing things that aren't there) in people with schizophrenia. Researchers want to see if this feedback can change brain activity in a specific area (the superior temporal gyrus) and reduce these hallucinations. You might be able to join if you are 18 to 55 years old, have schizophrenia or schizoaffective disorder, and your auditory hallucinations haven't improved with medication. The study will compare stg-rt-fMRI-Neurofeedback to sham-rt-fMRI-Neurofeedback, which provides feedback from a different brain area. The main goal is to see how much brain activity changes in the superior temporal gyrus after the intervention, measured up to four weeks later. The current status of this study is unclear, but it plans to enroll 104 participants.

Study design
This interventional study plans to enroll 104 participants. It compares two types of real-time fMRI neurofeedback: one targeting the superior temporal gyrus and a sham version targeting the somato-motor cortex.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured up to four weeks after the intervention.

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NCT05299749

Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations

Recruiting
NAAges 18–55InterventionalTreatment
Boston VA Research Institute, Inc.
~104 participants
Updated 2025-09-18 on ClinicalTrials.gov
What's tested:stg-rt-fMRI-Neurofeebacksham-rt-fMRI-Neurofeedback

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
percent change in the STG BOLD signal, post- relative to pre-NFB
Measured over 0-4 weeks post intervention
Schizophrenia
Auditory Hallucination
Treatment-resistant Schizophrenia
1 sites across 1 states
Massachusetts1
  • margaret niznikiewicz · PRINCIPAL_INVESTIGATOR · Boston VA Research Institute, Inc.

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Eligibility criteria

Inclusion

patients diagnosed with SZ or schizoaffective disorder using DSM-5 criteria
auditory hallucinations not responsive to pharmacology as determined by chart review and a clinical interview of SCID.

Exclusion

neurologic illness
major head trauma
electroconvulsive therapy
alcohol or drug dependence
alcohol or drug abuse within the past five years
verbal IQ below 70
  • percent change in the STG BOLD signal, post- relative to pre-NFB0-4 weeks post intervention

    does real-time fMRI neurofidback reduce BOLD activity in STG, post NFB