Study of Low-intensity Focused Ultrasound for Pain

This study is testing a treatment called low-intensity focused ultrasound (LIFU) to see how it affects brain signals related to pain. Researchers want to understand if LIFU can temporarily change brain activity, which could help with conditions like pain, addiction, or mental health issues in the future. You might be able to join if you are a healthy volunteer between 18 and 65 years old, understand and speak English, and don't have certain medical conditions or implants that would prevent you from having an MRI. The main goal is to measure changes in brain activity using fMRI (functional magnetic resonance imaging) scans over about three weeks. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 80 healthy volunteers. It is not specified if it's randomized, blinded, or its phase.
What's involved
You would have 4 study visits, which include MRI and CT scans, receiving LIFU, and fMRI scans to measure brain activity. You will also complete questionnaires and have your heart rate, blood pressure, and other vital signs monitored.
Compensation
Not stated in the trial record.
Follow-up
Your fMRI BOLD Signals will be measured over the participant study duration, which is approximately 3 weeks.

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NCT05303415

Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

Recruiting
NAAges 18–65InterventionalBasic science
Virginia Polytechnic Institute and State University
~80 participants
Updated 2026-06-08 on ClinicalTrials.gov
What's tested:Neuromodulation with low-intensity focused ultrasound

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
fMRI BOLD Signals
Measured over Participant study duration, approximately 3 weeks.
Pain
1 sites across 1 states
Virginia1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Healthy volunteers, all ethnicities, who understand and speak English.
  • fMRI BOLD SignalsParticipant study duration, approximately 3 weeks.

    Changes in fMRI BOLD signal