Feasibility Study of TheraSphere GBM for Recurrent Glioblastoma
This study is testing a new treatment called TheraSphere GBM for people with glioblastoma (a type of aggressive brain cancer) that has come back (recurrent). TheraSphere GBM uses tiny glass beads with radiation (yttrium-90) that are delivered directly to the tumor through a catheter (a thin tube) placed in a blood vessel. The goal is to deliver a high dose of radiation to the tumor while limiting side effects to healthy brain tissue. This study wants to see how safe TheraSphere GBM is by looking at serious side effects like non-blood-related issues, brain-specific problems, and radiation damage to the brain within 30 days after treatment. You might be able to join if you are 18 or older, have a confirmed diagnosis of glioblastoma, and are expected to live at least 12 weeks. This study is currently recruiting 36 participants.
- Study design
- This is a single-arm study, meaning all 36 participants will receive the TheraSphere GBM treatment. It is an interventional study, which means participants will receive a specific treatment.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study will follow participants for at least 30 days after the treatment to check for side effects.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM
At a glance
Conditions
Where it's being run
9 sites across 8 statesStudy leadership
- Riad Salem, M.D. · PRINCIPAL_INVESTIGATOR · Northwestern University
- Roger Stupp, M.D. · PRINCIPAL_INVESTIGATOR · Northwestern University
Who to contact
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What this trial measures
- The number of grade 3-5 non-hematological toxicities30 days post index procedure
- The number of ≥ grade 3 CNS toxicities related to non-target embolization30 days post index procedure
- Occurrence of symptomatic brain radiation necrosis requiring medical or surgical intervention and confirmed by pathology30 days post index procedure
- The number of Grade 4 neutropenia events persisting for longer than 5 days30 days post index procedure
- The number of grade 4 febrile neutropenia30 days post index procedure
- The number of grade 4 thrombocytopenia or grade 3 thrombocytopenia with hemorrhage30 days post index procedure