SGLT2 Inhibitors for Heart Attack Recovery

This study is testing if a medication called SGLT2 inhibitor can help your heart recover and reduce its enlargement after a heart attack. You may be able to join if you've had your first heart attack, had a procedure to open blocked arteries (primary PCI), and have some heart muscle weakness. The study will look at changes in the size of your heart's pumping chambers (LVESVI and LVEDVI) after six months. We are looking for 81 participants, but the current recruitment status is unclear.

Study design
This study is an interventional trial, meaning participants will receive either the SGLT2 inhibitor or a placebo. It aims to enroll 81 participants.
What's involved
You would take a pill once daily for six months, have a cardiac MRI during your initial hospitalization, receive follow-up phone calls at 1 and 3 months, and have another cardiac MRI and clinic visit at six months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for six months, with primary endpoints measured at that time.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05305911

Sodium Glucose Co-Transporter 2 (SGLT2) and STEMI

Recruiting
PHASE2Ages 18–75InterventionalTreatment
Minneapolis Heart Institute Foundation
~81 participants
Updated 2024-10-08 on ClinicalTrials.gov
What's tested:SGLT-2 inhibitorsPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in LVESVI
Measured over 6 Months
+1 more outcome measured
Heart Attack
Enlarged Heart
1 sites across 1 states
Minnesota1
  • Jay Traverse, MD · PRINCIPAL_INVESTIGATOR · Minneapolis Heart Institute Foundation

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients with their first STEMI (\>18 years) who underwent successful primary PCI and able to give informed consent
At least mild LV dysfunction (LVEF \< 50%) on echocardiogram, cMRI or Left Ventriculargram following PCI
Infarct size that is \> 10% of LV mass
The presence of MVO that is \> 10% of infarct size

Exclusion

Contraindication to cardiac MRI
Life expectancy \< 1 year
Previous CABG or Valve Surgery
Previous STEMI
Pregnant or planning to become pregnant or lactating women
Cardiogenic shock (not resolved)
Atrial fibrillation or recurrent sustained ventricular arrhythmias (excluding PVCs)
GFR\<30 ml/min/1.73m2 or end-stage renal disease on dialysis
Type 1 diabetes mellitus or history of diabetic ketoacidosis
Type I or II diabetes with insulin use
Prior intolerance of SGLT2 inhibitors
Current use of SGLT2 inhibitors (randomized patients only)
Contraindications to gadolinium
  • Change in LVESVI6 Months

    Change in LVESVI at 6 months as measured by MRI.

  • Change in LVEDVI6 Months

    Change in LVEDVI at 6 months as measured by MRI.