Evaluating Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
This study is looking at whether different types of deep brain stimulation (DBS) can improve thinking and memory in people with Parkinson's disease who already have a DBS device implanted. Researchers will compare "STN DBS - Theta Burst" stimulation to the standard "STN DBS - Gamma" stimulation. The goal is to see if one type of stimulation leads to better motor symptoms and executive functioning (like planning and problem-solving). You could be eligible if you are over 18, have had bilateral STN DBS surgery, and are on a stable medication plan. The study aims to enroll 40 participants, but its current status is unclear.
- Study design
- This is a randomized, double-blinded crossover study involving 32 participants. This means participants will receive both types of stimulation at different times, and neither you nor your doctor will know which stimulation is active.
- What's involved
- You will have several visits for motor and cognitive tests, and your DBS device settings will be changed. An fMRI scan will be done at the start, and again at 15 and 27 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your motor symptoms, executive functioning, and neuroimaging will be evaluated at 15 and 27 weeks after the study begins.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
At a glance
Conditions
NCT05307055
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Southern California Keck School of Medicine
Los Angeles, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Darrin Lee, MD PhD · PRINCIPAL_INVESTIGATOR · University of Southern California, Keck School of Medicine
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Evaluation of motor symptomsBaseline, Week 1, Week 2, Week 3, Week 15, Week 27
Effects of theta burst stimulation on changes in baseline motor symptoms will be assessed using the MDS-Unified Parkinson's Disease Rating Scale - Sections III\&IV (MDS-UPDRS III\&IV)
- Evaluation of executive functioningBaseline, Week 1, Week 2, Week 3, Week 15, Week 27
Effects of theta burst stimulation on changes in baseline cognitive symptoms will be assessed using Delis-Kaplan Executive Function System (D-KEFS).
- NeuroimagingBaseline, Week 15, Week 27
Effects of theta burst stimulation on changes in baseline resting state functional connectivity will be assessed using functional magnetic resonance imaging.