Labetalol or Nifedipine for Postpartum High Blood Pressure

This study is looking at two common medications, Labetalol and NIFEdipine ER, to see which one is better at preventing hospital readmissions for women who have high blood pressure (hypertension) after giving birth. You might be able to join if you are a woman aged 19 or older, delivering at 24 weeks gestation or more, and have high blood pressure (systolic blood pressure of 140 mmHg or higher, or diastolic blood pressure of 90 mmHg or higher) on two occasions at least four hours apart. The study aims to enroll 600 participants and will compare the risk of needing to be readmitted to the hospital within six months after delivery.

Study design
This is a randomized study, meaning participants will be randomly assigned to receive either Labetalol or NIFEdipine ER. The study plans to include 600 participants, with 300 in each treatment group.
What's involved
You would be started on either NIFEdipine XR 30mg twice a day or Labetalol 200mg three times a day. Your primary provider will adjust your medication as needed, and you will be monitored for side effects.
Compensation
Not stated in the trial record.
Follow-up
The study will track whether you are readmitted to the hospital for up to six months after delivery.

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NCT05309460

Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial

Recruiting
PHASE4Ages 19+InterventionalTreatment
Nebraska Methodist Health System
~600 participants
Updated 2024-04-12 on ClinicalTrials.gov
What's tested:Labetalol Oral TabletNIFEdipine ER

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Readmission
Measured over 6 months
Postpartum Preeclampsia
Hypertension in Pregnancy
1 sites across 1 states
Nebraska1
  • Todd Lovgren, MD · PRINCIPAL_INVESTIGATOR · Nebraska Methodist Health System

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Contraindication to either Nifedipine or Labetalol
HR \<60 or \>110
Native language other than English or Spanish
  • Readmission6 months

    Patients will be monitored following delivery for readmission to the hospital. To improve patient capture, all patients will be called at 6 months to identify complications or if hospital admission occured in the 6 months following delivery