This study is looking for 12 adults, aged 18-65, who have both obesity (BMI of 30 or higher) and high blood pressure. The goal is to see if blocking certain nerve signals (sympathetic blockade) can improve how your body produces glucose (sugar). You would receive three different treatments, each for two weeks: amlodipine (a blood pressure medicine), moxonidine (another blood pressure medicine), and a placebo (an inactive substance). The order you receive these will be random, and neither you nor the study staff will know which treatment you are getting at any given time. The main way we'll measure success is by looking at your body's natural glucose production after each two-week treatment period.

Study design

This is a randomized, crossover study involving 12 participants. You will receive each of the three treatments in a random order, and neither you nor the researchers will know which treatment you are on at the time.

What's involved

You will receive three different treatments, each for two weeks. After each two-week period, you will undergo a six-hour test to measure your body's glucose production.

Compensation

Not stated in the trial record.

Follow-up

Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.