Brain Glucose Metabolism in Type 1 Diabetes Study
This study is looking at how a medication called Dichloroacetate affects brain function in people with Type 1 Diabetes (T1D) who have experienced severe low blood sugar (hypoglycemia) or don't notice when their blood sugar is low (hypoglycemia unawareness). Researchers want to see if Dichloroacetate can help maintain your thinking skills when blood sugar is low. You might be able to join if you are between 18 and 55 years old, have T1D, and have a history of severe hypoglycemia or hypoglycemia unawareness. The study aims to see if Dichloroacetate can help the brain use glucose (sugar) better during low blood sugar events. The current status of this study is unclear.
- Study design
- This is a randomized, placebo-controlled, double-blind crossover pilot study with 16 planned participants. This means some participants will receive Dichloroacetate and others a placebo (inactive substance), and neither you nor the researchers will know which you are receiving.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your cognitive function will be measured at 1 day after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Raimund Herzog, MD · PRINCIPAL_INVESTIGATOR · Yale University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Cognitive Function1 day
Measures of reaction time \[in milliseconds\] and cognitive testing performance under hypoglycemia \[percentage\].