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Study on Oxalate and Citrate for Kidney Stone Prevention

This study is looking at how two substances, oxalate and citrate, might affect your risk of forming kidney stones. Researchers want to understand if consuming sodium oxalate, a form of oxalate, changes the levels of oxalate and citrate in your urine. You could join if you are between 18 and 70 years old and have a history of calcium-based kidney stones, or if you are a healthy individual without kidney stones. The study involves drinking a special sodium oxalate drink during an all-day visit to the University of Chicago research clinic. Researchers will measure changes in your urine oxalate and citrate levels over 6 hours to see if dietary oxalate affects this balance. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 50 participants. It is a single-center study.
What's involved
You would collect urine at home the day before your visit. Then, you would spend an all-day visit at the University of Chicago research clinic, where you would consume a special drink (sodium oxalate).
Compensation
Not stated in the trial record.
Follow-up
The primary measurements for this study are taken up to 6 hours after consuming the sodium oxalate drink.

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NCT05334979

Oxalate and Citrate

Recruiting
NAAges 18–70InterventionalPrevention
University of Chicago
~50 participants
Updated 2026-01-08 on ClinicalTrials.gov
What's tested:Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in concentration of urine oxalate from baseline to 2-hours, 4-hours, and 6-hours after sodium oxalate consumption
Measured over 6 hours
+2 more outcomes measured

Conditions

Kidney Stone
Normal Controls

Explore related trials

Healthy ControlNephrolithiasis

Where it's being run

1 sites across 1 states
Illinois1

Who to contact

Megan Prochaska, MD
[email protected]
(773) 702-1000 · ext. 45488
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Eligibility criteria

Inclusion

Age 18-70
History of at least one calcium-based kidney stone
Age 18-70
No history of kidney stone
24-hour urine oxalate within lab normal (\<50mg/day)

Exclusion

History of primarily uric acid, cysteine, or struvite stones.
History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

What this trial measures

  • Change in concentration of urine oxalate from baseline to 2-hours, 4-hours, and 6-hours after sodium oxalate consumption6 hours

    Concentration of urine oxalate will be measured or calculated at time points 0, 2-hours, 4-hours, and 6-hours after sodium oxalate consumption. We will compare change in urine citrate and fractional excretion of citrate by change in oxalate at each time period for all participants.

  • Change in concentration of urine citrate from baseline to 2-hours, 4-hours, and 6-hours after sodium oxalate consumption.6 hours

    Concentration of urine citrate will be measured or calculated at time points 0, 2-hours, 4-hours, and 6-hours after sodium oxalate consumption. We will compare change in urine citrate and fractional excretion of citrate by change in oxalate at each time period for all participants.

  • Change in fractional excretions of citrate and oxalate from baseline to 2-hours, 4-hours, and 6-hours after sodium oxalate consumption.6 hours

    Fractional excretion of citrate will be measured or calculated at time points 0, 2-hours, 4-hours, and 6-hours after sodium oxalate consumption. We will compare change in urine citrate and fractional excretion of citrate by change in oxalate at each time period for all participants.