Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes

This study is looking at how non-nutritive sweeteners (NNS) like aspartame and sucralose affect blood sugar control (glucose homeostasis) in people aged 40 and older who have prediabetes. Researchers want to see if consuming these sweeteners changes how your body handles sugar, especially compared to not using any NNS. You could be given aspartame, sucralose, or no NNS as part of a controlled diet. The main goal is to measure your 24-hour blood sugar levels after 6 weeks to understand these effects. To join, you need to be at least 40 years old, have prediabetes (fasting glucose 100-125 mg/dL, 2-hour oral glucose tolerance test 140-199 mg/dL, or HbA1c 5.7%-6.4%), and be weight-stable. The study is currently unclear on its recruitment status and plans to enroll 30 participants.

Study design: This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 30 participants.
What's involved: Participants will need to pick up food as part of a controlled feeding study. The study measures 24-hour glycemic control at 6 weeks.
Compensation: Not stated in the trial record.
Follow-up: The primary endpoint for measuring blood sugar control is at 6 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes

Recruiting

NAAges 40+InterventionalPrevention

Virginia Polytechnic Institute and State University

~30 participants

Updated 2025-12-04 on ClinicalTrials.gov

What's tested:Non-Nutritive Sweetener Intake and impact on glucose homeostasis

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

24-hour glycemic control

Measured over 6 weeks

Conditions

Continuous Glucose Monitoring

Oral Glucose Tolerance

Insulin Sensitivity

Inflammatory Markers

Where it's being run

1 sites across 1 states

Virginia1

Study leadership

Valisa Hedrick, PhD · PRINCIPAL_INVESTIGATOR · Virginia Polytechnic Institute and State University

Who to contact

Valisa Hedrick, PhD

[email protected]

540-231-7983

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 40+ years

Prediabetic (fasting glucose concentration of 100-125 mg/dL, 2-hour oral glucose tolerance test glucose concentration of 140-199 mg/dL, or a HbA1c value of 5.7% to 6.4%)

Weight stable for previous 6 months (±2 kg)

BMI \<40 kg/m2

Sedentary to recreationally active

No plans to gain/lose weight or change physical activity level

Willing to pick up food daily and consume foods provided for an 8-week period

Verbal and written informed consent

Approval by Medical Director

Consume less than one serving of non-nutritive sweetener per week

Exclusion

BMI \>40 kg/m2

Diabetes or diabetes medication

Antibiotic, prebiotic or prebiotic use in prior 3 months

Uncontrolled hypertension (blood pressure (BP) \> 159/99 mmHg)

Diagnosed inflammatory bowel disease

Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease

Vegetarian or vegan

Pregnant or plans to become pregnant

Breastfeeding

Food allergies or aversions, Phenylketonuria (PKU)

Estrogen or testosterone usage

What this trial measures

24-hour glycemic control6 weeks
The area under the curve (AUC) glucose concentrations, mg/dl from the continuous glucose monitoring at baseline and follow-up will be used

Trialytics