This study, called INDICT, is looking at new ways to treat severe traumatic brain injury (TBI). If you or a loved one has had a severe TBI and needs emergency surgery within 72 hours, you might be able to join. The study will use a diagnostic test called Full-band Electrocorticography to monitor brain activity for something called 'spreading depolarizations' (a type of brain wave that can cause damage). Based on these readings, a Treatment Algorithm will guide doctors on how to adjust care to prevent these depolarizations. The main goal is to see how well this approach reduces the number of spreading depolarizations during your time in intensive care, up to two weeks after the injury. The study is currently unclear on its recruitment status and plans to enroll 72 participants.

Study design

This is a randomized Phase 2 study that plans to enroll 72 participants to test a new treatment approach for traumatic brain injury.

What's involved

You would undergo Full-band Electrocorticography monitoring and receive care guided by a Treatment Algorithm during your intensive care stay, up to two weeks after injury.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint is measured during the period of intensive care invasive monitoring, up to two weeks after injury.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.