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Study on Menthol's Effect on E-Cigarette Users

This study is looking at how menthol-flavored e-cigarettes affect users compared to tobacco-flavored e-cigarettes. Researchers want to understand if menthol changes how much nicotine your body takes in. You might be able to join if you are a generally healthy e-cigarette user between 21 and 35 years old. The study aims to enroll 250 participants. The study is currently unclear on its recruitment status, but it is interventional, meaning you will receive specific e-cigarette types during the study. Success will be measured by changes in the amount of nicotine in your blood after using each type of e-cigarette.

Study design
This is an interventional study planning to enroll 250 participants. All participants will use both menthol-flavored and tobacco-flavored e-cigarettes.
What's involved
You will attend lab visits where you will use a menthol-flavored e-cigarette and a tobacco-flavored e-cigarette for up to 60 minutes each. Blood samples will be taken before and after each e-cigarette use session.
Compensation
Not stated in the trial record.
Follow-up
Blood nicotine levels will be measured during two participant visits, before and after each e-cigarette use session.

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NCT05338801

Effect of Menthol on ENDS Users' Addiction and Exposure

Recruiting
NAAges 21–35InterventionalPrevention
Florida International University
~250 participants
Updated 2026-04-01 on ClinicalTrials.gov
What's tested:Menthol-flavored e-cigaretteTobacco-flavored e-cigarette

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Plasma nicotine
Measured over During the 2 participant visits. Blood will be taken 2 times in each e-cigarette use session: before and after an approximately 60 minutes ad lib use period

Conditions

Electronic Cigarette Use

Explore related trials

Electronic Cigarette Use

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Wasim Maziak, PhD, MD · PRINCIPAL_INVESTIGATOR · Florida International University

Who to contact

Wasim Maziak, PhD, MD
[email protected]
3053484501
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Generally healthy individuals (determined by physical examination).
Age of 21-35 years.
Is willing to provide informed consent.
Is willing to attend the lab as required by the study protocol.
E-cigarette users (defined as using e-cigarette either daily or occasionally in the past 30 days)
Have abstained from e-cigarette use for 12 hours prior to each session

Exclusion

Report smoking cigarettes regularly (\> 5 cigarettes/month in the past year).
Report regular use of any other tobacco/nicotine product (e.g., e-cig, pipes, cigars) in the past year.
Women who are breast-feeding or test positive for pregnancy (by urinalysis at screening).
Individuals with self-reported history of chronic disease or psychiatric conditions.
Individuals with history of or active cardiovascular disease, low or high blood pressure, seizures, and regular use of prescription medications (other than vitamins or birth control).
Individuals that report current THC (marijuana) smoking/vaping.
Individuals that report current EVALI or COVID-19 related symptoms (i.e., cough, shortness of breath, chest pain, nausea, vomiting, abdominal pain, diarrhea, fever, chills, or weight loss)
Individuals that have or have been exposed to COVID-19 in the last 14 days.

What this trial measures

  • Plasma nicotineDuring the 2 participant visits. Blood will be taken 2 times in each e-cigarette use session: before and after an approximately 60 minutes ad lib use period

    Change in plasma nicotine level