Observational Study on Pulsatility During Cardiopulmonary Bypass

This study is looking at how the type of blood flow during cardiopulmonary bypass (a machine that takes over for your heart and lungs during surgery) affects your body after cardiac surgery. When you have heart surgery, a machine called a cardiopulmonary bypass machine helps circulate your blood. This machine can create blood flow that is either steady (non-pulsatile) or more like your natural heartbeat (pulsatile). Researchers want to see if one type of blood flow is better for your organs, specifically looking at endothelial function (how well the lining of your blood vessels works) and acute kidney injury (sudden kidney damage). You may be able to join if you are between 50 and 70 years old and are scheduled for elective cardiac surgery with cardiopulmonary bypass. The study will measure endothelial function from when you are admitted to the intensive care unit after surgery until you leave the hospital, up to 30 days.

Study design
This is an observational study with a planned enrollment of 66 participants. It will compare patients who receive pulsatile or non-pulsatile cardiopulmonary bypass during cardiac surgery.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed from intensive care unit admission after surgery to hospital discharge, up to 30 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05344573

Optimizing Pulsatility During Cardiopulmonary Bypass

Recruiting
Not specifiedAges 50–70Observational
University of Colorado, Denver
~66 participants
Updated 2024-11-21 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Endothelial function
Measured over From intensive care unit admission after surgery to hospital discharge, up to 30 days
Endothelial Dysfunction
Acute Kidney Injury
1 sites across 1 states
Colorado1
  • Nathan J Clendenen, MD, MS · PRINCIPAL_INVESTIGATOR · University of Colorado Denver | Anschutz

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age 50 to 70
Able to provide informed consent
Scheduled for elective cardiac surgery with cardiopulmonary bypass

Exclusion

Patients undergoing emergency procedures
Diagnosed with sepsis
Experiencing delirium
Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90)
Patients with a mechanical circulatory support device
Requiring vasoactive medications before surgery
Patients with a reduced left ventricular ejection fraction (less than 50%)
Patients with a contraindication to transesophageal echocardiography
  • Endothelial functionFrom intensive care unit admission after surgery to hospital discharge, up to 30 days

    Percent change in flow mediated dilation of the brachial artery after cardiac surgery