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NCT05345392

Brain, Emotions, and Mind-Wandering

Active, Not Recruiting
NAAges 11–14InterventionalPrevention
University of Pittsburgh
~224 participants
Updated 2026-06-08 on ClinicalTrials.gov
What's tested:Mindfulness-Based Intervention (MBI)Health and Wellness Intervention (HWI)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
PCC-FPCN rsFC: Seed-based
Measured over PCC-FPCN rsFC will be assessed up to 3 months after completing the MBI/HWI group.
+2 more outcomes measured

Conditions

Mood Disorders

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Mood Disorder

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Danella Hafeman, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Males and females between the ages of 11-14 years
Parent or full biological sibling with major depressive disorder and/or bipolar I/II disorder
Elevated mood lability, which is defined as \>10 on the Children's Affective Lability Scale (averaging the child and parent score).

Exclusion

IQ\<70 or significant learning disability (which will make it difficult to participate in study procedures)
Current or previous diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or autism spectrum disorder
Current diagnosis of major depressive disorder
Contraindications to scanning, including metal in the body (e.g. has braces or planning to get braces within the next 8 months)
Suicidal or homicidal ideation within the past month
Changed medications or medication doses (including psychotropic medications and/or hormonal contraceptives), or have started a new therapy, within the past two months.

What this trial measures

  • PCC-FPCN rsFC: Seed-basedPCC-FPCN rsFC will be assessed up to 3 months after completing the MBI/HWI group.

    During each visit, the investigators will collect 10 minutes of resting-state data (eyes open; 2 runs, 5 minutes each), using Framewise Integrated Real-time MRI Monitoring (FIRMM) to ensure high quality. Following preprocessing, the investigators will assess resting-state functional connectivity between the posterior cingulate cortex (PCC; 0,-62,24; 4mm radius) and the frontoparietal control network (FPCN). The investigators will use mixed models to assess changes over time in the MBI vs. HWI group.

  • SART AccuracySART accuracy will be assessed up to 3 months after completing the MBI/HWI group.

    Participants will complete a Sustained Attention to Response Task (SART). In this task, numbers 1-9 will be sequentially displayed on the screen. Participants will be asked to press the space bar for every number except for "3". Overall target discrimination (d') will be assessed by calculating and z-transforming the "false alarm rate" (% omission errors, i.e. failing to press the space bar when indicated) and subtracting it from the z-transformed "hit rate" (% correct omissions, i.e. accurately not pressing the space bar to "3"). The investigators will use mixed models to assess changes over time in the MBI vs. HWI group.

  • SART: Mind-wandering Awareness ProbeMind-wandering during the SART will be assessed up to 3 months after completing the MBI/HWI group.

    Participants will complete a Sustained Attention to Response Task (SART). In this task, numbers 1-9 will be sequentially displayed on the screen. Participants will be asked to press the space bar for every number except for "3". To assess mind-wandering awareness, following each block of 10, 14, 18, 22, or 26 trials, participants will be asked to rate on 5-point likert scales "Where was your attention focused just now?"; and "How aware were you of where your attention was?". Self-report probes will be classified as on-task (responses 1-2 on 5-point "on-task" scale); off-task aware (responses 3-5 on 5-point "on-task" scale + responses 1-2 on 5-point "aware" scale); or off-task unaware (responses 3-5 on 5-point "on-task" scale + responses 3-5 on 5-point "aware" scale). The investigators will use mixed models to assess changes over time in the MBI vs. HWI group.