This study is looking at the best way to help family members get tested for certain genetic conditions like Long QT Syndrome and Familial Hypercholesterolemia. These conditions are linked to specific gene changes (KCNQ1 Thr224Met or APOB R3527Q). If you carry one of these gene changes, you could be eligible. The study compares two ways to reach out to your first-degree relatives (like parents, siblings, or children): either the study team directly contacts them, or you contact them yourself. The main goal is to see which method leads to more family members getting screened. This is an interventional study, meaning you'll be assigned to one of these two groups. The current status of the study is unclear.

Study design

This is an interventional study that will randomly assign 200 participants to either a direct or indirect family contact group. It is not specified if the study is blinded.

What's involved

If you are a proband, you will consent and be randomized. If in the indirect arm, you will contact your family members. If in the direct arm, you will be advised that study staff will contact your family members, and you will also be instructed to contact them prior to the study team. Family members will receive pre-test counseling, free in-home saliva-based genetic testing, and post-test counseling.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, uptake of cascade screening, will be measured through study completion, which is approximately 4 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.