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Iron Supplementation for Right Ventricular Function and Exercise in Low-Oxygen Conditions

This study is looking at whether taking iron supplement pills can improve how well people exercise when they are in low-oxygen conditions (hypoxia). Hypoxia can make the right side of your heart (right ventricle) work harder. Participants will take one tablet of ferrous sulfate 325 mg (an iron supplement) daily for 30 days. Researchers will measure your maximum workload and how much oxygen you use during exercise to see if the iron helps. This study is for men and premenopausal women aged 18 to 60 years old who do not have serious heart or lung conditions. The study plans to enroll 5 participants, but its current status is unclear.

Study design
This is an interventional study with an unspecified phase, planning to enroll 5 participants. It is a follow-up to a separate study.
What's involved
You would take one ferrous sulfate 325 mg tablet daily for 30 days. Your maximum workload and maximal oxygen uptake will be measured up to 1 hour.
Compensation
Not stated in the trial record.
Follow-up
Your exercise performance will be measured up to 1 hour after the intervention period.

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NCT05349630

Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia

Not Yet Recruiting
EARLY_PHASE1Ages 18–60InterventionalPrevention
University of Colorado, Denver
~5 participants
Updated 2026-04-29 on ClinicalTrials.gov
What's tested:Ferrous sulfate 325mg

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maximum workload
Measured over Up to 1 hour
+1 more outcome measured

Conditions

Right Ventricular Dysfunction
Hypoxia

Explore related trials

HypoxiaRight Ventricular Dysfunction

Where it's being run

1 sites across 1 states
Colorado1

Who to contact

William Cornwell, MD
[email protected]
303-724-2085
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Eligibility criteria

Inclusion

Age 18 - 60
For women, premenopausal status

Exclusion

Active cardiovascular or pulmonary disease (e.g. hypertension, coronary artery disease, cardiomyopathy, arrhythmia, valvular abnormalities, diabetes, peripheral vascular disease, tobacco use, chronic obstructive pulmonary disease, asthma, interstitial lung disease, restrictive lung disease, or pulmonary hypertension)
Use of cardiac- or pulmonary-related medications
Prior history of high altitude pulmonary edema or high altitude cerebral edema
Body mass index \< 18.5 or \> 30
Anemia
Iron deficiency
Iron supplementation (oral or intravenous) in the preceding 60 days
Systemic anticoagulation or aspirin use that cannot be temporarily held for the study
Pregnancy
Non-cardiopulmonary disorders that adversely influence exercise ability (e.g. arthritis or peripheral vascular disease)
Dedicated athletic training (defined here as spending \>9 hours per week in vigorous physical activity \[≥6 mets\])
Regular high-altitude exercise (defined here as engaging in vigorous physical activity \[≥1 hour at ≥6 mets\] at ≥8,000 ft for \>2 days per week over the preceding 4 weeks)
Residence at ≥8,000 ft for 3 or more consecutive nights in the preceding 30 days

What this trial measures

  • Maximum workloadUp to 1 hour

    Workload in Watts at peak exercise on upright cycle ergometer

  • Maximal oxygen uptakeUp to 1 hour

    Maximal oxygen uptake at peak exercise (VO2max) in L/min