Intrathecal Morphine for Pain After Thoracic Surgery

This study is looking at whether a single dose of morphine given into the spinal fluid (intrathecal morphine) can help reduce pain after certain lung surgeries. These surgeries are called video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracic surgery (RATS). You might be able to join if you are between 18 and 80 years old and are having one of these elective lung surgeries. The study aims to see if patients who receive intrathecal morphine use less pain medication in the 24 hours after surgery compared to those who receive a placebo (sterile saline). The current status of this study is unclear.

Study design
This is a randomized, placebo-controlled, double-blinded study with 90 planned participants. Participants will be randomly assigned to receive either morphine sulfate or a placebo.
What's involved
You will receive either morphine or saline during your surgery. You will complete a questionnaire before leaving the hospital and participate in phone surveys 1 and 3 months after surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed up with phone surveys at 1 and 3 months after surgery.

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NCT05351229

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Recruiting
PHASE4Ages 18–80InterventionalPrevention
Northwestern University
~90 participants
Updated 2026-06-09 on ClinicalTrials.gov
What's tested:Morphine SulfatePlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Postoperative morphine equivalent consumption
Measured over 24 hours after surgery
Pain, Postoperative
1 sites across 1 states
Illinois1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18-80 years old
Undergoing elective video-assisted thoracoscopic or robotic assisted surgery for anatomical lung resection
General anesthesia with anticipated intraoperative extubation.

Exclusion

American Society of Anesthesiologists (ASA) classification of 4 or 5
Anticipated postoperative intubation
Significant liver disease
Preoperative use of intravenous inotropes and/or vasopressor support
Preoperative mechanical ventilation
Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)
Severe pulmonary disease (home oxygen requirement and/or current oral steroid use)
Morphine allergy
Opioid or alcohol abuse
Chronic pain
Renal failure
Inability to comprehend English language
Bleeding disorder
Abnormal preoperative coagulation
Infection
Patient refusal
Failed spinal
  • Postoperative morphine equivalent consumption24 hours after surgery

    Total MG of analgesic medications given converted to morphine