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Exercise Training and Fat Metabolism in Postmenopausal Women

This study is looking at how different types of exercise affect fat metabolism (how your body breaks down and uses fat) in postmenopausal women. We are comparing two types of exercise: resistance exercise (weightlifting) and endurance exercise (treadmill walking). Each exercise program lasts for 12 weeks. You may be able to join if you are a woman between 50 and 75 years old, are postmenopausal, have obesity, and have prediabetes. We want to see if these exercises can improve how your body handles fat, which could help prevent type 2 diabetes. We will measure changes in fat breakdown in different areas of your body.

Study design
This interventional study plans to enroll 120 women to compare the effects of resistance exercise versus endurance exercise.
What's involved
Participants will engage in either weightlifting or treadmill walking three times a week for 12 weeks. Procedures will involve measurements of fat breakdown before and after this training.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken at 12 weeks after starting either resistance or endurance training.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05351476

Exercise Training and Fat Metabolism in Postmenopausal Women

Recruiting
NAAges 50–75InterventionalBasic science
Florida State University
~120 participants
Updated 2026-04-13 on ClinicalTrials.gov
What's tested:Resistance ExerciseEndurance Exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline subcutaneous abdominal adipose tissue glycerol concentration at 12 weeks
Measured over 12 weeks of resistance or endurance training
+2 more outcomes measured

Conditions

Postmenopausal Symptoms
Obesity
Prediabetic State

Explore related trials

ObesityPrediabetes

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Robert C Hickner, PhD · PRINCIPAL_INVESTIGATOR · Florida State University
  • Michael J Ormsbee, PhD · PRINCIPAL_INVESTIGATOR · Florida State University
  • Mostafa M Ali, PhD · STUDY_DIRECTOR · Florida State University

Who to contact

Robert C Hickner, PhD
[email protected]
850-644-1375
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Women
Postmenopausal (50-75 yrs.)
Obese (BMI 30-50 kg/m2)
Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
Non-smokers
No hormone replacement therapy for at least the past two years.

Exclusion

Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
Type 1 or type 2 diabetes
Medical problems in which exercise is contraindicated, such as chronic infections
History of, or currently presentation with, cancer, cardiovascular or respiratory disease
Uncontrolled thyroid dysfunction, liver or renal dysfunction
Taking any medication affecting lipid metabolism
Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
Smokers and those with diagnosed eating disorders

What this trial measures

  • Change from baseline subcutaneous abdominal adipose tissue glycerol concentration at 12 weeks12 weeks of resistance or endurance training

    Changes in physical activity (walking)-stimulated lipolysis will be assessed as measured by glycerol concentration in dialysate samples from subcutaneous abdominal adipose tissue utilizing a powerful in-vivo microdialysis methodology

  • Change from baseline gluteal adipose tissue glycerol concentration at 12 weeks12 weeks of resistance or endurance training

    Changes in physical activity (walking)-stimulated lipolysis will be assessed as measured by glycerol concentration in dialysate samples from gluteal adipose tissue utilizing a powerful in-vivo microdialysis methodology

  • Change from baseline whole-body lipolysis at 12 weeks12 weeks of resistance or endurance training

    Whole body lipolysis will be measured using whole body rate of appearance of 2H5-glycerol in blood samples collected at rest, during walking exercise, and for 120 minutes after exercise.