Mild Intermittent Hypoxia for Autonomic Dysfunction in Spinal Cord Injuries
This study is investigating if breathing "Mild Intermittent Hypoxia" (air with less oxygen) can help prevent autonomic dysfunction in people with spinal cord injuries. Autonomic dysfunction can cause problems like Autonomic Dysreflexia (sudden, dangerous high blood pressure) and Orthostatic Hypotension (low blood pressure when standing up). Currently, there isn't an effective way to prevent these issues. You might be able to join if you are 18-60 years old, have an incomplete spinal cord injury at or above the T12 level, and show signs of autonomic dysfunction. The researchers will measure Autonomic Dysreflexia at different times: before the intervention, 6 minutes after, 1 day after, and 2 weeks after. The study status is unclear and plans to enroll 24 participants.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 24 participants, but the specific design (like if it's randomized or blinded) is not specified.
- What's involved
- Participants will breathe either 8% oxygen (Mild Intermittent Hypoxia) or 21% oxygen (Sham) through a facemask system. The duration or frequency of these sessions is not detailed.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for up to 2 weeks after the intervention to measure Autonomic Dysreflexia.
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Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Gino Panza, PhD · PRINCIPAL_INVESTIGATOR · John D. Dingell VA Medical Center, Detroit, MI
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Autonomic Dysreflexia6 minutes, Pre-Intervention, 1 Day after intervention (i.e. post intervention)
Change in systolic blood pressure during thigh occlusion test.