Mild Intermittent Hypoxia for Autonomic Dysfunction in Spinal Cord Injuries

This study is investigating if breathing "Mild Intermittent Hypoxia" (air with less oxygen) can help prevent autonomic dysfunction in people with spinal cord injuries. Autonomic dysfunction can cause problems like Autonomic Dysreflexia (sudden, dangerous high blood pressure) and Orthostatic Hypotension (low blood pressure when standing up). Currently, there isn't an effective way to prevent these issues. You might be able to join if you are 18-60 years old, have an incomplete spinal cord injury at or above the T12 level, and show signs of autonomic dysfunction. The researchers will measure Autonomic Dysreflexia at different times: before the intervention, 6 minutes after, 1 day after, and 2 weeks after. The study status is unclear and plans to enroll 24 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 24 participants, but the specific design (like if it's randomized or blinded) is not specified.
What's involved
Participants will breathe either 8% oxygen (Mild Intermittent Hypoxia) or 21% oxygen (Sham) through a facemask system. The duration or frequency of these sessions is not detailed.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 2 weeks after the intervention to measure Autonomic Dysreflexia.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05351827

Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries

Recruiting
NAAges 18–60InterventionalTreatment
VA Office of Research and Development
~24 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:Mild Intermittent HypoxiaSham

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Autonomic Dysreflexia
Measured over 6 minutes, Pre-Intervention, 1 Day after intervention (i.e. post intervention)
Spinal Cord Injuries
Autonomic Dysreflexia
1 sites across 1 states
Michigan1
  • Gino Panza, PhD · PRINCIPAL_INVESTIGATOR · John D. Dingell VA Medical Center, Detroit, MI

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Motor incomplete spinal cord injury at or above the 12th thoracic vertebrae
Signs or symptoms of autonomic dysfunction (this will be determined by the Autonomic Dysfunction Following Spinal Cord Injury (ADFSCI) and ISAFSCI questions. The ADFSCI requires a score of 1 on questions 16 and 22, and the International Standards to document Autonomic Function following SCI (ISAFSCI) requires a score of 1 on any parameter)
Chronic injuries (\>1 year post injury)

Exclusion

Pregnant
Smoker
Drug addiction
Complete spinal cord injury
Spinal cord injury below the 6th thoracic vertebrae
Insulin dependent diabetes
Shift workers (i.e., disrupted circadian rhythm)
Active skin breakdown or pressure sores
  • Autonomic Dysreflexia6 minutes, Pre-Intervention, 1 Day after intervention (i.e. post intervention)

    Change in systolic blood pressure during thigh occlusion test.