Home-based tDCS for ADHD

This study is investigating if a home-based treatment called transcranial direct current stimulation (tDCS) can help improve symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) and thinking skills. tDCS is a non-invasive (does not break the skin) technique that uses a mild electrical current. Researchers want to see if different strengths of tDCS (1 mA or 2 mA) are more effective than a sham (inactive) treatment. They will also look at how well people can use this treatment at home. The study plans to enroll 60 adults between 18 and 65 years old who have an ADHD diagnosis. Success will be measured by changes in brain activity (P300 Amplitude), overall functioning (GAF Scale), and ADHD symptoms (Adult ADHD Self-Report Scale) over eight weeks.

Study design
This interventional study plans to enroll 60 participants. It compares two different strengths of tDCS (1 mA and 2 mA) to a sham (inactive) treatment.
What's involved
You would receive daily tDCS treatments at home for 30 days. Your brain activity, overall functioning, and ADHD symptoms will be measured between week 1 and week 8 of the study.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be monitored for eight weeks after the study begins.

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NCT05354232

Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Attention-deficit/Hyperactivity Disorder (ADHD)

Recruiting
NAAges 18–65InterventionalTreatment
Massachusetts General Hospital
~60 participants
Updated 2025-12-12 on ClinicalTrials.gov
What's tested:2 mA transcranial direct current stimulation (tDCS)1 mA transcranial direct current stimulation (tDCS)Sham transcranial direct current stimulation (tDCS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
P300 Amplitude during Erickson Flanker Task
Measured over Week 1 - Week 8 of Study
+2 more outcomes measured
Attention Deficit Disorder
Attention Deficit Disorder With Hyperactivity
1 sites across 1 states
Massachusetts1
  • Joan Camprodon, MD, PHD, MPH · PRINCIPAL_INVESTIGATOR · MGB: Division of Neuropsychiatry and Neuromodulation

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  • P300 Amplitude during Erickson Flanker TaskWeek 1 - Week 8 of Study

    P300, an electrophysiological feature theorized to represent executive functioning, has been previously shown to be notably diminished during the Erickson Flanker Task (EFT) . We will be administering this task to assess changes in P300 during the EFT, and if any changes are related to subjects' assigned condition.

  • Global Assessment of Functioning (GAF) ScaleWeek 1 - Week 8 of Study

    investigators will use GAF scale to assess the potential feasibility of at-home tDCS for future research.

  • Adult ADHD Self-Report ScaleWeek 1 - Week 8 of Study

    Investigators will assess changes to these questionnaires in reference to assigned stimulation group to assess changes to ADHD symptomatology across study duration.