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Comparing Propofol and Etomidate Admixtures for Anesthesia

This study, called the PEAC Trial, is comparing two different mixtures of anesthesia medications, propofol and etomidate, for patients having endoscopic procedures. One mixture is 75% propofol and 25% etomidate (P7E2), and the other is 25% propofol and 75% etomidate (P2E7). Researchers want to see which mixture leads to more stable blood pressure (hemodynamics) and fewer side effects (adverse events). You might be able to join if you are an adult (18 or older), having an endoscopic procedure at Clements University Hospital, have certain health conditions (ASA 3 or above), and have had an Ejection Fraction test. The study aims to find the best ratio for safe anesthesia in this patient group.

Study design
This is a randomized controlled double-blind trial, meaning participants are randomly assigned to one of the two medication mixtures, and neither you nor your doctors will know which mixture you are receiving. The study plans to enroll 200 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your blood pressure, vasopressor use, and oxygen levels will be monitored throughout the entire study, which is estimated to take 6 to 12 months to complete.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05358535

Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)

Recruiting
PHASE3Ages 18+InterventionalTreatment
University of Texas Southwestern Medical Center
~200 participants
Updated 2026-01-20 on ClinicalTrials.gov
What's tested:Admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2)Admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time weighted average mean arterial pressure within treatment arm
Measured over Throughout entire study estimated to take 6 to 12 months to complete
+11 more outcomes measured

Conditions

Anesthesia
Propofol Adverse Reaction
Etomidate Adverse Reaction
Anesthesia Complication
Anesthesia; Adverse Effect
Anesthesia; Reaction

Explore related trials

Anesthesia Procedure

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Kapil Anand · STUDY_DIRECTOR · University of Texas

Who to contact

Christopher Choi
[email protected]
2146486400
Email the study team

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What this trial measures

  • Time weighted average mean arterial pressure within treatment armThroughout entire study estimated to take 6 to 12 months to complete

    Time weighted average mean arterial pressure (every 15 minutes calculate average mean arterial pressure for that interval, then end of case calculate mean of all those means for the entire case)

  • Average within treatment arm vasopressor use by number of unitsThroughout entire study estimated to take 6 to 12 months to complete

    Vasopressor use by number of units (1 unit of vasopressor being defined as 1 unit vasopressor = 100 mcg phenylephrine = 5 mg ephedrine = 0.5 units vasopressin = 5 mcg norepinephrine)4-9 throughout entire intraoperative period (subjects on vasopressor infusions on arrival for endoscopy will not have those vasopressor units added in UNLESS during case, anesthesia clinicians adjust the infusion based on intraoperative clinical situation as well as all bolus doses and new infusions being added as with all other subjects)

  • Average within treatment arm total minutes under 92% oxygen saturationThroughout entire study estimated to take 6 to 12 months to complete

    Average within treatment arm total minutes under 92% oxygen saturation by pulse oximetry during entire case

  • % of cases with any MAP below 50Throughout entire study estimated to take 6 to 12 months to complete

    % of cases with any MAP below 50

  • % of cases with any MAP >60% below patient's immediate preoperative MAPThroughout entire study estimated to take 6 to 12 months to complete

    % of cases with any MAP \>60% below patient's immediate preoperative MAP

  • % of cases with any treatment for Post Operative Nausea and VomitingThroughout entire study estimated to take 6 to 12 months to complete

    % of cases with any treatment for Post Operative Nausea and Vomiting

  • % of cases with any oxygen saturation event below 85% by pulse oximetryThroughout entire study estimated to take 6 to 12 months to complete

    % of cases with any oxygen saturation event below 85% by pulse oximetry

  • % of cases with any rapid response or code blue event within 24 hours from anesthesia startThroughout entire study estimated to take 6 to 12 months to complete

    % of cases with any rapid response or code blue event within 24 hours from anesthesia start

  • Within treatment arm % of total group with a composite MACE event in the 30 daysThroughout entire study estimated to take 6 to 12 months to complete

    Within treatment arm % of total group with a composite MACE event in the 30 days after starting on day of drug administration

  • Within treatment arm % of total group with a classic MACE event in the 30 daysThroughout entire study estimated to take 6 to 12 months to complete

    Within treatment arm % of total group with a classic MACE event in the 30 days after starting on day of drug administration

  • Average within treatment arm antiemetic use by number of dosesThroughout entire study estimated to take 6 to 12 months to complete

    Average within treatment arm antiemetic use by number of doses irrespective of antiemetic drug choice

  • Average within treatment arm time in minutes after dressing complete to dischargeThroughout entire study estimated to take 6 to 12 months to complete

    Average within treatment arm time in minutes after dressing complete to discharge to next phase of care or to home from immediate recovery phase of care