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Melatonin for Uterine Contractions in Pregnant Women

This study is investigating how melatonin affects uterine contractions in pregnant women. Researchers are testing oral melatonin (a dietary supplement) against a placebo (an inactive pill) to see if it changes the number of contractions. They are looking at the total number of contractions during the daytime (over 10 hours) and nighttime (over 4 hours). You may be able to join if you are a woman between 18 and 35 years old, pregnant with one baby, at least 38 weeks along, and have not given birth before. You also need to have a pre-pregnancy BMI (Body Mass Index) under 36. The study aims to enroll 120 participants, but its current status is unclear.

Study design
This interventional study plans to enroll 120 participants. It compares melatonin to a placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints measure contractions over 10 hours during the day and 4 hours at night.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05358834

Testing Effects of Melatonin on Uterine Contractions in Women

Recruiting
NAAges 18–35InterventionalBasic science
Brigham and Women's Hospital
~120 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:MelatoninPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Daytime: Total number of uterine contractions
Measured over 10 hours
+1 more outcome measured

Conditions

Pregnant Women

Explore related trials

Pregnancy

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Elizabeth B Klerman, MD PhD · PRINCIPAL_INVESTIGATOR · MGH

Who to contact

Elizabeth B Klerman, MD PhD
[email protected]
617-643-2424
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

nulliparity, age between 18 and 35,
BMI\<36 pre-pregnancy,
≥38 weeks of pregnancy with a single fetus at time of study.

Exclusion

color blind;
prescription drugs affecting sleep, melatonin, and/or circadian rhythms (e.g., beta blockers, non-steroidal anti-inflammatory drugs);
a health or pregnancy related condition that might affect melatonin or uterine contractions;
medical conditions or medications for which melatonin might be contraindicated or there may be a drug interactions (e.g., Central Nervous System depressants/sedatives, Fluvoxamin (Luvox), medications for diabetes, immunosuppressants, anti-coagulants, Nifedipine, Verapamil).

What this trial measures

  • Daytime: Total number of uterine contractions10 hours

    Daytime: Total number of uterine contractions

  • Nighttime: Total number of uterine contractions4 hours

    Nighttime: Total number of uterine contractions