This study is looking at how hormones and a type of therapy called Exposure and Response Prevention (EX/RP) affect the brains of people with Obsessive-Compulsive Disorder (OCD). EX/RP is a common treatment for OCD that involves facing your fears and not doing your usual rituals. Researchers want to see how hormones, especially during a woman's menstrual cycle, impact how well EX/RP works and how it changes the brain's fear network. You might be able to join if you are 18-45 years old, have an OCD diagnosis, and for women, are menstruating regularly. You also can't have taken certain medications recently. The study will measure changes in your brain using fMRI (a type of brain scan) and your OCD symptoms over about 4 weeks. The study's current status is unclear.

Study design

This is an interventional study planning to enroll 120 participants. Female participants will be randomly assigned to receive EX/RP during different phases of their menstrual cycles.

What's involved

Participants will complete neuroimaging (fMRI scans), provide samples for hormonal tests, and have their OCD symptoms rated before and after a brief 8-session course of EX/RP, which takes about 4 weeks.

Compensation

Not stated in the trial record.

Follow-up

OCD symptoms and fMRI changes will be measured at baseline and approximately 4 weeks later.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.