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Observational Study on Atrial Fibrillation and Ablation Success

This observational study aims to better understand atrial fibrillation (AF), a condition causing rapid heartbeats, stroke, or heart failure. Researchers want to find out if the size of organized regions in your heart, measured before an ablation or Maze surgery, can predict how successful the procedure will be. The study will follow 200 participants aged 22 to 80 who are scheduled for ablation or Maze surgery at Stanford Medicine for persistent AF. You would be eligible if you have persistent AF (lasting more than 7 days or requiring cardioversion to stop) and have not responded to or cannot tolerate at least one anti-arrhythmic drug. The main goal is to see if the area of organized regions in AF predicts success from ablation after one year.

Study design
This is an observational study with a planned enrollment of 200 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, success from ablation, will be measured at 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05366361

The Dynamics of Human Atrial Fibrillation

Recruiting
Not specifiedAges 22–80Observational
Stanford University
~200 participants
Updated 2026-02-17 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Does the Area of Organized Regions in AF predict success from Ablation?
Measured over 1 year.

Conditions

Atrial Fibrillation
Arrhythmias, Cardiac

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Atrial Fibrillation

NCT05366361

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Stanford University

    Stanford, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Anson Lee, MD
[email protected]
(650) 724-7500
Email the study team

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Eligibility criteria

Inclusion

referred for ablation or Maze surgery at Stanford Medicine for persistent AF (i.e. which requires cardioversion to terminate and/or lasts \>7 days)
Per our clinical practice and guidelines (Calkins et al., Heart Rhythm 2018), patients will have failed or be intolerant of \>or= 1 anti-arrhythmic drug. Patients after Maze surgery typically have failed prior endocardial ablation.

Exclusion

active coronary ischemia or decompensated heart failure
atrial or ventricular clot on trans-esophageal echocardiography
pregnancy (to minimize fluoroscopic exposure)
inability or unwillingness to provide informed consent
rheumatic valve disease (results in a unique AF phenotype)
thrombotic disease or venous filters
prior chest surgery is a relative contraindication for Maze surgery

What this trial measures

  • Does the Area of Organized Regions in AF predict success from Ablation?1 year.

    We will map areas of organized activity in all patients. We will compare if patients with success from ablation (absence of recurrent AF or atrial tachycardia on outpatient monitoring) have larger organized areas than those without success.