South Asians and Coronary Plaque Registry

This observational study, called the South Asians and Coronary Plaque Registry, aims to understand why South Asian individuals may have a higher risk of heart disease. Researchers will use a Coronary CT Angiogram (CCTA), which is a special X-ray test, to look at the arteries that supply blood to your heart and identify plaque characteristics. You can join if you are 18 or older and identify as South Asian, or if you are a non-South Asian adult volunteer for comparison. The study hopes to gather information about plaque features to help with future research into heart disease in this group. The current status of the study is unclear, but it plans to enroll 300 participants.

Study design
This is an observational study that plans to enroll 300 participants, including South Asian adults and a comparison group of non-South Asian adults.
What's involved
If you participate, you will complete a survey about your health, have blood drawn, and undergo a Coronary CT Angiogram (CCTA).
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, which looks at plaque features, is measured at Day 1.

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NCT05367297

South Asians and Coronary Plaque Registry

Recruiting
Not specifiedAges 18+Observational
University of Texas Southwestern Medical Center
~300 participants
Updated 2025-08-28 on ClinicalTrials.gov
What's tested:Coronary CT Angiogram

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number and type of adverse and protective CTA-derived plaque features Number and type of adverse and protective CTA-derived plaque features
Measured over Day 1
Coronary Artery Disease
Heart Diseases
1 sites across 1 states
Texas1
  • Anand Rohatgi, MD · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center

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Eligibility criteria

Inclusion

Males and Females: Age 18 years or above
South Asian (SA) adults through self-identification (South Asians to have both biological parents with ancestry from India, Pakistan, Sri Lanka, Nepal and Bangladesh)
We also propose to enroll an equivalent number of individuals of other descent as a comparator group (Non SA Adult Volunteers)
Sampling Method: Probability Sample

Exclusion

Under the age of 18 years
Unable to give informed consent
Impaired renal function: estimated glomerular filtration rate ≤ 45ml/min
Baseline heart rate≥70 bpm or ≥66 bpm after beta blocker
Body mass index (BMI) of 35 or greater
Prior anaphylactic/non-anaphylactic reaction or other contraindication to iodinated contrast
Anyone who cannot do CCTA for any reason
Pregnancy
  • Number and type of adverse and protective CTA-derived plaque features Number and type of adverse and protective CTA-derived plaque featuresDay 1

    There will be several features derived from CTA that are validated adverse features, including plaque volume, thin cap, low attenuation, and necrotic core. Protective features include fibrous cap thickness.