Adaptive Optics Retinal Imaging for Glaucoma
This study is looking at new ways to take very detailed pictures of the retina (the light-sensitive tissue at the back of your eye) using special cameras called adaptive optics scanning laser ophthalmoscopy (AOSLO) and adaptive optics - optical coherence tomography (AO-OCT). Researchers want to see how these images can help us understand glaucoma, specifically primary open-angle glaucoma (POAG). They will measure changes in blood flow in your retina when you breathe pure oxygen, and also look at the density and size of certain nerve cells in your eye called retinal ganglion cells (RGCs). The goal is to improve how we use this imaging technology in clinics. This study is currently recruiting 150 participants, including those with POAG.
- Study design
- This is an interventional study involving 150 participants, including both healthy volunteers and individuals with primary open-angle glaucoma (POAG).
- What's involved
- You would participate in a single imaging session where your retinal blood flow will be measured before and during oxygen inhalation. For some participants, RGC density and size will be measured three times over 1.5 years.
- Compensation
- Not stated in the trial record.
- Follow-up
- Some participants will have their RGC density and size quantified three times over 1.5 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Adaptive Optics Retinal Imaging
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Daniel X Hammer, Ph.D. · PRINCIPAL_INVESTIGATOR · Food and Drug Administration (FDA)
Who to contact
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What this trial measures
- Change in Retinal blood flow (RBF) with oxygen inhalationRBF will be measured in all subjects twice during a single AO imaging session - once before and once during pure oxygen inhalation. Subjects will be imaged only once; there is no longitudinal component to this outcome measure.
RBF \[uL/min\] will be measured from ensemble RBC velocity \[mm/s\] measurements from line-scan AOSLO videos and vessel diameter \[mm\] measurements from average AO-OCT volumes.
- Retinal ganglion cell (RGC) densityRGC density will be calculated once at the AO imaging session in which RGCs are the target. For the reproducibility/longitudinal study portion, RGC density will be quantified three times over 1.5 years (visits separated by 6 months).
RGC density will be calculated at specific retinal eccentricities from cells counted in average AO-OCT volumes.
- RGC soma diameterRGC diameter will be calculated once at the AO imaging session in which RGCs are the target. For the reproducibility/longitudinal portion of the study, RGC soma diameter will be quantified three times over 1.5 years (visits separated by 6 months).
RGC soma diameter will be calculated at specific retinal eccentricities from cells segmented in average AO-OCT volumes.
- Retinal pigment epithelium (RPE) cell organelle motilityRPE organelle motility will be calculated once at the AO imaging session in which RPE cells are the target. For the reproducibility portion of the study, RPE organelle motility will be quantified three times over six weeks (visits separated by 2 weeks).
RPE cell organelle motility will be calculated from the decorrelation time constant for cells segmented from a sequence of AO-OCT volumes.
- Photoreceptor (PR) cell functionPR function will be calculated once at the AO imaging session in which photoreceptors are stimulated. For the reproducibility portion of the study, PR function will be quantified three times over six weeks (visits separated by 2 weeks).
Photoreceptor cell (cone) function will be measured from phase changes between inner segment - outer segment junction and cone outer segment tip signals in a sequence of AO-OCT volumes collected during visible light stimulation.