Comprehensive Behavioral Intervention for Tics (CBIT) for Tic Disorders
This study is looking at how well a treatment called Comprehensive Behavioral Intervention for Tics (CBIT) works for young people with tic disorders. CBIT is a behavioral therapy that involves at least six 50-minute sessions, either individually or in a group. Researchers want to understand what makes this intervention successful and for whom. To join, you must be between 5 and 17 years old, have a tic disorder diagnosis or bothersome tic symptoms, and be able to speak and read English. At least one parent or caregiver also needs to be available. The study will measure success by looking at changes in tic severity and improvement, as well as parent-reported tic symptoms, over 12 weeks.
- Study design
- This is an interventional study planning to enroll 200 participants. The phase of the study is not specified.
- What's involved
- Participants will receive a minimum of 6 sessions of 50-minutes each week, either individually or in a group setting. Assessments will occur at pre-screen, baseline, 6 weeks, and 12 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 12 weeks from the start of treatment.
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Comprehensive Behavioral Intervention for Tics
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jill Ehrenreich-May, Ph.D. · STUDY_DIRECTOR · University of Miami
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Clinical Global Impression (CGI) - Severity Scale ScoresChange from baseline CGI-S scores to 12 weeks.
A single-item clinician-reported measure used to assess the severity of the youth's illness at the time of assessment. The CGI-S is rated on a 7-point scale ranging from 1 (slight psychiatric illness) to 7 (extremely severe psychiatric illness). Higher scores indicate greater symptom severity.
- Clinical Global Impression (CGI) - Improvement ScoresChange from baseline CGI-I scores to 12 weeks from the start of treatment.
A single-item clinician-reported measure used to assess clinical changes in youth symptomology over the course of treatment. The CGI-I is rated on a 7-point scale ranging from 1 (very much improved since the initiation of treatment) to 7 (very much worse since the initiation of treatment). Higher scores indicate greater symptom improvement since baseline
- Parent Tic Questionnaire (PTQ)Change from pre-screen PTQ scores, to baseline, to 6 weeks, and 12 weeks from the start of treatment.
A 28-item parent-reported measure used to assess the frequency and intensity of different motor and vocal tic symptoms in youth. The PTQ evaluates tic frequency on a 4-point scale, ranging from 1 (constant) to 4 (weekly), and intensity on a 3-point scale, ranging from 1 (mild) to 3 (very noticeable). This is done for each presenting tic. Composite total scores on the PTQ range from 2-138. Higher summed composite score indicating more tics.
- Premonitory Urge Tic Scale (PUTS)Change from baseline PUTS scores, to 6 weeks, to 12 weeks from the start of treatment.
A 10-item self-reported measure that assess the severity of premonitory urges. The PUTS is rated on a 4-point scale ranging from 1 (not at all true) to 4 (very much true). Total scores range from 10-40 with higher scores indicating greater symptom severity.
- Youth Quality of Life (YQOL) Instrument - Short Form (SF) ScoresChange from baseline YQOL Scores, to 6 weeks, to 12 weeks from the start of treatment.
A 15-item self-reported measure of quality of life for youth ages 11-18. The YQOL-SF is rated on a 10-point scale from 0 (not at all) to 10 (very much). Scores range from 0 to 100, with higher scores indicating a higher quality of life.
- Yale Global Tic Severity Scale (YGTSS) - Total Tic ScoresChange from pre-screen YGTSS Total Tic Scores, to 6 weeks, and 12 weeks from the start of treatment.
The YGTSS is a clinician-rated interview assessing both motor and phonic tic symptoms across 5 domains: total number, frequency, intensity, complexity, and interference. Items from each domain for motor and phonic tics are summed to produce the YGTSS Total Tic Score, which ranges from 0-50. Higher scores on the YGTSS - Total Tic Score suggests greater tic severity.
- Yale Global Tic Severity Scale (YGTSS) - Total Motor Tic ScoresChange from pre-screen YGTSS Total Motor Tic Scores, to 6 weeks, and 12 weeks from the start of treatment.
The YGTSS is a clinician-rated interview assessing both motor and phonic tic symptoms across 5 domains: total number, frequency, intensity, complexity, and interference. Items from each domain for motor tics are summed to produce the YGTSS Total Motor Tic Score, which ranges from 0-25. Higher scores on the YGTSS - Total Motor Score suggests greater motor tic severity.
- Yale Global Tic Severity Scale (YGTSS) - Total Phonic Tic ScoreChange from pre-screen YGTSS Total Phonic Tic Scores, to 6 weeks, and 12 weeks from the start of treatment.
The YGTSS is a clinician-rated interview assessing both motor and phonic tic symptoms across 5 domains: total number, frequency, intensity, complexity, and interference. Items from each domain for phonic tics are summed to produce the YGTSS Total Phonic Tic Score, which ranges from 0-25. Higher scores on the YGTSS - Total Phonic Score suggests greater phonic tic severity.
- Yale Global Tic Severity Scale (YGTSS) - Overall Tic Related Impairment ScoresChange from YGTSS Overall Tic Related Impairment Scores pre-screen, to 6 weeks, and 12 weeks from the start of treatment.
The YGTSS is a clinician-rated interview assessing both motor and phonic tic symptoms across 5 domains: total number, frequency, intensity, complexity, and interference. The YGTSS includes a separate impairment scale that reflects overall tic-related impairment, ranging from 0-50. Higher scores on this scale suggests greater tic impairment.
- Yale Global Tic Severity Scale (YGTSS) - Global Severity ScoreChange from pre-screen YGTSS Global Severity Score, to 6 weeks, and 12 weeks from the start of treatment.
The YGTSS is a clinician-rated interview assessing both motor and phonic tic symptoms across 5 domains: total number, frequency, intensity, complexity, and interference. The YGTSS includes a separate global severity scale that ranges from 0-100. Higher scores on this scale suggests greater global tic severity.