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Advanced Cardiac CT Reconstruction for Structural Heart Disease

This study is looking at new ways to improve heart CT scans for people with structural heart disease. Doctors use CT scans (computed tomography) to get detailed pictures of your heart. This study will compare standard CT images with new, super high-resolution images created using advanced computer techniques from the same scan. The goal is to see if these new methods create better pictures. You may be able to join if you are 18 or older and are already scheduled for a contrast-enhanced cardiac CT scan for structural heart disease. The study aims to determine if these advanced images are superior to standard ones, with results expected in 5 years. The study is currently unclear on its recruitment status.

Study design
This is an observational study involving about 1000 participants. It compares different ways of processing CT scan data.
What's involved
You will undergo a normal, clinically-indicated CT scan with a substance injected through your arm. Your participation concludes at the end of this standard clinical CT examination.
Compensation
Not stated in the trial record.
Follow-up
The primary objective will be measured at 5 years, but your direct participation ends after your CT scan.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05372627

NHLBI-Emory Advanced Cardiac CT Reconstruction

Not Yet Recruiting
Not specifiedAges 18+Observational
National Heart, Lung, and Blood Institute (NHLBI)
~1,000 participants
Updated 2026-09-17 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The objective of this research protocol is to determine whether advanced mathematical image reconstructions create superior images compared with standard cardiac CT image reconstruction in patients with structural heart disease.
Measured over 5 years

Conditions

Structural Heart Disease

Explore related trials

Structural Heart Disease

NCT05372627

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Emory University Midtown Hospital

    Atlanta, Georgiastudy coordinator listed

  • National Institutes of Health Clinical Center

    Bethesda, Marylandstudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Marcus Y Chen, M.D. · PRINCIPAL_INVESTIGATOR · National Heart, Lung, and Blood Institute (NHLBI)

Who to contact

Margaret C Lowery, R.N.
[email protected]
(301) 412-9255
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

What this trial measures

  • The objective of this research protocol is to determine whether advanced mathematical image reconstructions create superior images compared with standard cardiac CT image reconstruction in patients with structural heart disease.5 years

    The primary endpoint is a semi-quantitative measure of superiority of advanced mathematical image reconstruction compared with standard cardiac CT image reconstruction for study-specific fine detail. Specifically, the endpoint is a Likert-like scale assessing visibility of small structures or fine detail.