Comparing Treatments for Lennox-Gastaut Syndrome
This study is looking at the effectiveness of two different approaches for Lennox-Gastaut syndrome (LGS), a severe form of epilepsy that starts in childhood. Researchers want to compare palliative surgery (surgery to relieve symptoms) with adding more anti-seizure medications. The goal is to see which approach is better at reducing emergency healthcare visits related to seizures and limiting the impact on daily abilities. You may be able to join if you have Lennox-Gastaut syndrome and your medical records are at one of the seven plus eleven pediatric centers. The study will measure how well these treatments work over two years. The current status of this study is unclear.
- Study design
- This is an observational study, meaning researchers will look at existing medical records. It plans to include 4680 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study will measure outcomes related to seizure-related emergency healthcare for two years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome
At a glance
Conditions
NCT05374824
Where you'd take part
This study runs at 4 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinoisstudy coordinator listed
Recruiting
C.S. Mott Children's Hospital
Ann Arbor, Michiganstudy coordinator listed
Recruiting
Nationwide Children's
Columbus, Ohiostudy coordinator listed
Recruiting
St. Louis Children's Hospital
St Louis, Missouristudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Sandi Lam, MD MBA · PRINCIPAL_INVESTIGATOR · Ann & Robert H Lurie Children's Hospital of Chicago
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Seizure-related emergency health care utilization2 years
Emergency health-care utilization for Aim 1a will be defined as the frequency per year of seizure-related emergency department visits and separately seizure-related inpatient admissions in the two years postintervention (surgery or medical), with adjustment for the rate during the year prior to intervention.