Computerized Training for Obsessive-Compulsive and Related Disorders
This study is testing a computerized training program called Response Inhibition Training (RIT) for people with Obsessive-Compulsive Disorder (OCD), Trichotillomania (compulsive hair pulling), or Skin-Picking Disorder. The goal is to see if RIT can improve your ability to stop unwanted actions and reduce your symptoms. You might receive 8 to 16 sessions of either RIT or a placebo (inactive) computerized training. To join, you need to be between 18 and 60 years old, have moderate symptoms of one of these conditions, and show some difficulty with response inhibition. The study will measure changes in your symptom severity over about 8 to 12 weeks. The current recruitment status is unclear.
- Study design
- This study is an interventional trial planning to enroll 118 participants. Participants will be randomly assigned to receive either the computerized cognitive training or a computerized placebo training.
- What's involved
- You will receive 8 to 16 sessions of 45-minute computerized training. Your symptom severity will be measured at Week 0, Week 4, and Week 8-12.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your symptom severity will be followed for approximately 8 to 12 weeks after the start of the study.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Neural Mechanisms of Response Inhibition Training for OCRD
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Hanjoo Lee, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Milwaukee
- Christine Larson, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Milwaukee
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in obsessive-compulsive disorder symptom severity over timeWeek 0, Week 4, Week 8 ~ 12
Depending on participant's primary diagnostic condition, Yale-Brown Obsessive Compulsive Scale (YBOCS) will be used as the primary outcome measure for assessing the change in OCD symptoms over time. The total score ranges between 0 and 40 with higher scores indicating worse outcomes (= more severe symptoms).
- Change in compulsive hair pulling symptom severity over timeWeek 0, Week 4, Week 8 ~ 12
Depending on participant's primary diagnostic condition, National Institute of Mental Health - Trichotillomania Symptom Severity Scale (NIMH-TSS) will be used as the primary outcome measure for assessing the change in hair pulling symptoms over time. The total score ranges between 0 and 25 with higher scores indicating worse outcomes (= more severe symptoms).
- Change in compulsive skin picking symptom severity over timeWeek 0, Week 4, Week 8 ~ 12
Depending on participant's primary diagnostic condition, Yale-Brown Obsessive Compulsive Scale modified for Neurotic Excoriation (NE-YBOCS) will be used as the primary outcome measure for assessing the change in skin picking symptoms over time. The total score ranges between 0 and 40 with higher scores indicating worse outcomes (= more severe symptoms).
- Change in activation in the right inferior frontal cortex (rIFC)Week 0, Week 4
Change in the level of blood-oxygen-level-dependent (BOLD) signal activation in the right inferior frontal cortex (rIFC) will be assessed using the stop-signal task (SST) that will be administered while the participant undergoes a functional magnetic resonance imaging procedure.