Stellate Ganglion Block for Ventricular Tachycardia

This study is looking at how a treatment called a left-sided percutaneous stellate ganglion block affects the heart's electrical activity in people with ventricular tachycardia (a fast, abnormal heart rhythm). The stellate ganglion block involves injecting a drug near nerves in your neck. Researchers want to see if this block changes the Ventricular Effective Refractory Period (how long it takes for your heart's lower chambers to be ready for another beat) 30 minutes after the block. You may be able to join if you are at least 18 years old and are already scheduled for a catheter-based VT ablation (a procedure to correct the abnormal heart rhythm). You cannot join if you are pregnant, have certain medical conditions, or are allergic to the local anesthetic used. The current recruitment status is unclear, and the study plans to enroll 20 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It is a prospective cohort study, which means researchers will follow a group of participants over time.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured 30 minutes after the stellate ganglion block.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05377216

Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation

Recruiting
EARLY_PHASE1Ages 18+InterventionalBasic science
University of Pennsylvania
~20 participants
Updated 2025-11-21 on ClinicalTrials.gov
What's tested:Stellate Ganglion Block

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ventricular Effective Refractory Period
Measured over 30 minutes following stellate ganglion block
Ventricular Tachycardia

NCT05377216

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvaniano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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Eligibility criteria

Inclusion

Planned catheter based VT ablation
Age at least 18 years

Exclusion

Pregnancy
Contraindication to SGB or VT ablation
Hypersensitivity of local anesthetic of amide type
Hemodynamic instability during the procedure prior to the study protocol
  • Ventricular Effective Refractory Period30 minutes following stellate ganglion block

    Change in Ventricular Effective Refractory Period at 600ms drive train (measured in milliseconds)