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Oxygen Supplementation and Breathing Recovery After Surgery

This study is looking at how different levels of oxygen given after surgery affect your breathing recovery. Researchers will compare giving more oxygen (Oxyhemoglobin saturation (SpO2) higher than 96%) versus a standard amount (SpO2 between 90% and 94%) for 90 minutes right after anesthesia. The main goal is to see how long your carbon dioxide levels (TcPCO2) stay above a certain point. You may be able to join if you are between 18 and 70 years old, have a BMI under 40, and are having robotic-assisted radical laparoscopic nephrectomy or prostatectomy surgery. People with certain lung, heart, or neurological conditions cannot join. This study plans to enroll 60 participants, but its current status is unclear.

Study design
This is a randomized-controlled study, meaning participants are randomly assigned to one of two oxygen groups. It plans to enroll 60 participants.
What's involved
You would receive different levels of oxygen for 90 minutes immediately after anesthesia. Your carbon dioxide levels will be measured during this time.
Compensation
Not stated in the trial record.
Follow-up
Your breathing recovery will be monitored for a 90-minute period immediately after anesthesia.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05379673

The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia

Recruiting
NAAges 18–70InterventionalPrevention
Stanford University
~60 participants
Updated 2025-05-16 on ClinicalTrials.gov
What's tested:Oxygen Gas for Inhalation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Transcutaneous partial pressure of carbon dioxide (TcPCO2)
Measured over Ninety -minute period beginning immediately post-anesthesia.

Conditions

Ventilatory Depression
Postoperative Respiratory Failure

Explore related trials

Postoperative Respiratory FailureRespiratory Depression

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Anthony Doufas, MD, PhD · PRINCIPAL_INVESTIGATOR · Professor, Department of Anesthesiology, Stanford University Medical School

Who to contact

Anthony Doufas, MD, PhD
[email protected]
650-498-7699
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

American Society of Anesthesiologists (ASA) physical status I-III
Body mass index (BMI) less than 40 kg/m2
Scheduled to undergo robotic-assisted radical laparoscopic nephrectomy or prostatectomy.

Exclusion

Patients with a diagnosis of chronic obstructive pulmonary disorder (COPD), severe neurological, cardiopulmonary, psychiatric, or untreated thyroid disorder
Chronic pain condition that is being treated with opioids
Patients with a hematocrit lower than 30% at the end of surgery, or those with an excessive blood loss, requiring transfusion of blood products during surgery.

What this trial measures

  • Transcutaneous partial pressure of carbon dioxide (TcPCO2)Ninety -minute period beginning immediately post-anesthesia.

    The cumulative segment of time during which the transcutaneous partial pressure of carbon dioxide (TcPCO2: primary outcome) will exceed an upper limit of 45 mmHg (i.e., TcPCO2 \> 45 mmHg)